Title : Peptide screening to knockdown Bcl-2's anti-apoptotic activity: implications in cancer treatment.

Pub. Date : 2012 Apr 1

PMID : 22155216






2 Functional Relationships(s)
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1 In this study we have identified BH3 domain of Bax (Bax BH3) as potentially the best Bcl-2 antagonist by performing docking of BH3 peptides (peptides representing BH3 domain of pro-apoptotic and BH3-only proteins) into the Bcl-2 hydrophobic groove formed by BH3, BH1 and BH2 domains (also referred as BH3 cleft). BH 3 BCL2 associated X, apoptosis regulator Homo sapiens
2 In this study we have identified BH3 domain of Bax (Bax BH3) as potentially the best Bcl-2 antagonist by performing docking of BH3 peptides (peptides representing BH3 domain of pro-apoptotic and BH3-only proteins) into the Bcl-2 hydrophobic groove formed by BH3, BH1 and BH2 domains (also referred as BH3 cleft). BH 3 BCL2 associated X, apoptosis regulator Homo sapiens