Pub. Date : 2016 Jul 2
PMID : 27172402
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux. | BH 3 | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 2 | Here we confirm that small molecule BH3 mimetics can induce BAX- and BAK1-independent MAP1LC3B/LC3B lipidation, but this only occurred at concentrations far greater than required to induce apoptosis and dissociate canonical BH3 domain-containing proteins that bind more tightly than BECN1. | BH 3 | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 3 | Therefore at concentrations that are on target and achievable in vivo, BH3 mimetics only induce autophagy in a BAX- and BAK1-dependent manner. | BH 3 | BCL2 associated X, apoptosis regulator | Homo sapiens |