| 1 |
35194983 | Evolutionary impacts of purine metabolism genes on mammalian oxidative stress adaptation. | 2022 Mar 18 |
1 |
| 2 |
30895693 | Chromosome Transplantation: Correction of the Chronic Granulomatous Disease Defect in Mouse Induced Pluripotent Stem Cells. | 2019 Jul |
1 |
| 3 |
29306799 | Purine salvage in plants. | 2018 Mar |
1 |
| 4 |
29416770 | HPRT1 activity loss is associated with resistance to thiopurine in ALL. | 2018 Jan 5 |
1 |
| 5 |
26067813 | Do clinical features of Lesch-Nyhan disease correlate more closely with hypoxanthine or guanine recycling? | 2016 Jan |
1 |
| 6 |
26968365 | Crystal structures of Apo and GMP bound hypoxanthine-guanine phosphoribosyltransferase from Legionella pneumophila and the implications in gouty arthritis. | 2016 Jun |
1 |
| 7 |
26368337 | Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases. | 2015 Oct |
1 |
| 8 |
26902413 | Kinetic mechanism of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. | 2015 Dec |
1 |
| 9 |
21904906 | Urate nephropathy associated with impaired kinetic properties of hypoxanthine phosphoribosyl transferase in a 45-day-old infant. | 2012 Feb |
2 |
| 10 |
22157001 | Genotype-phenotype correlations in Lesch-Nyhan disease: moving beyond the gene. | 2012 Jan 27 |
1 |
| 11 |
21486037 | Hypoxanthine guanine phosphoribosyltransferase distorts the purine ring of nucleotide substrates and perturbs the pKa of bound xanthosine monophosphate. | 2011 May 17 |
2 |
| 12 |
21054786 | Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1. | 2010 Dec |
2 |
| 13 |
18710792 | Is ZMP the toxic metabolite in Lesch-Nyhan disease? | 2008 Nov |
1 |
| 14 |
15990111 | The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. | 2005 Aug 5 |
3 |
| 15 |
15571222 | Clinical and biochemical manifestations and molecular characterization of the mutation HPRT Jerusalem. | 2004 Oct |
1 |
| 16 |
15571295 | Potential role of mycophenolate mofetil in the management of neuroblastoma patients. | 2004 Oct |
1 |
| 17 |
12829005 | Chemical diagnosis of Lesch-Nyhan syndrome using gas chromatography-mass spectrometry detection. | 2003 Jul 15 |
1 |
| 18 |
11241585 | Hypoxanthine impairs morphogenesis and enhances proliferation of a neuroblastoma model of Lesch Nyhan syndrome. | 2001 Mar 15 |
1 |
| 19 |
11307586 | The spectrum of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. Clinical experience based on 22 patients from 18 Spanish families. | 2001 Mar |
1 |
| 20 |
11562934 | Molecular analysis of HPRT1(+) somatic cell hybrids derived from a carrier of an HPRT1 mutation responsible for Lesch-Nyhan syndrome. | 2001 Sep 15 |
1 |
| 21 |
10657589 | Kelley-Seegmiller syndrome due to a unique variant of hypoxanthine-guanine phosphoribosyltransferase: reduced affinity for 5-phosphoribosyl-1-pyrophosphate manifested only at low, physiological substrate concentrations. | 2000 Feb 21 |
2 |
| 22 |
10833458 | Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes. | 2000 Jun 7 |
2 |
| 23 |
10976110 | Converting the guanine phosphoribosyltransferase from Giardia lamblia to a hypoxanthine-guanine phosphoribosyltransferase. | 2000 Nov 24 |
1 |
| 24 |
10850548 | Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium. | 1999 Dec |
4 |
| 25 |
9521733 | Catalysis in human hypoxanthine-guanine phosphoribosyltransferase: Asp 137 acts as a general acid/base. | 1998 Mar 24 |
4 |
| 26 |
9670994 | Impaired differentiation of HPRT-deficient dopaminergic neurons: a possible mechanism underlying neuronal dysfunction in Lesch-Nyhan syndrome. | 1998 Jul 1 |
1 |
| 27 |
9860824 | Approaching the transition state in the crystal structure of a phosphoribosyltransferase. | 1998 Dec 8 |
3 |
| 28 |
9092930 | Mutagenic activity of high-energy 532 nm ultra-short laser pulses. | 1997 Apr |
1 |
| 29 |
8976093 | [Hypoxanthine guanine phosphoribosyl transferase]. | 1996 Dec |
1 |
| 30 |
8032345 | Role of differentiation induction in action of purine antimetabolites. | 1994 Apr 15 |
1 |
| 31 |
8128888 | The effect of high-intensity training on purine metabolism in man. | 1993 Dec |
1 |
| 32 |
1445289 | Use of the HPRT gene and the HAT selection technique in DNA-mediated transformation of mammalian cells: first steps toward developing hybridoma techniques and gene therapy. | 1992 Jul |
1 |
| 33 |
1487231 | A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. | 1992 Nov |
2 |
| 34 |
1583701 | Metabolic fate of hypoxanthine and inosine in cultured cardiomyocytes. | 1992 Feb |
1 |
| 35 |
1731938 | Steady-state kinetics of the schistosomal hypoxanthine-guanine phosphoribosyltransferase. | 1992 Jan 28 |
1 |
| 36 |
1712904 | Functional characterization of the human hypoxanthine phosphoribosyltransferase gene promoter: evidence for a negative regulatory element. | 1991 Aug |
1 |
| 37 |
1850982 | Artemia purine phosphoribosyltransferases. Purification and characterization. | 1991 Apr 15 |
2 |
| 38 |
1886405 | The pathogenesis of the Lesch-Nyhan syndrome: ATP use is positively related to hypoxanthine supply to hypoxanthine guanine phosphoribosyltransferase. | 1991 |
2 |
| 39 |
2071157 | Determination of the mutations responsible for the Lesch-Nyhan syndrome in 17 subjects. | 1991 Jun |
2 |
| 40 |
2543233 | Modified GMP-affinity chromatography for the purification of mutant hypoxanthine phosphoribosyltransferase. | 1989 Apr |
2 |
| 41 |
2567208 | Biochemically directed therapy of leukemia with tiazofurin, a selective blocker of inosine 5'-phosphate dehydrogenase activity. | 1989 Jul 1 |
1 |
| 42 |
3148065 | Lesch-Nyhan syndrome and its pathogenesis: purine concentrations in plasma and urine with metabolite profiles in CSF. | 1988 |
3 |
| 43 |
3221837 | Isolation and characterization of mammalian cell lines carrying suppressible mutations. | 1988 Jul |
1 |
| 44 |
2437821 | A method for the determination of 5-phosphoribosyl 1-pyrophosphate concentrations in erythrocytes using high-performance liquid chromatography. | 1987 Feb 1 |
1 |
| 45 |
3435682 | Major determinants of purine excretion from human lymphoblasts. | 1987 Dec |
2 |
| 46 |
3456059 | Induction of hypoxanthine phosphoribosyltransferase deficiency in human U-937 cells. | 1986 Feb |
1 |
| 47 |
3941107 | Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni. A potential target for chemotherapy. | 1986 Jan 15 |
1 |
| 48 |
3939543 | Intracellular activity of HPRT Cape Town: purine uptake and growth of cultured cells in selective media. | 1985 |
2 |
| 49 |
6204922 | Partial deficiency of hypoxanthine-guanine phosphoribosyltransferase with reduced affinity for PP-ribose-P in four related males with gout. | 1984 |
1 |
| 50 |
6327016 | Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues. | 1984 Jun |
1 |