Title : Partial deficiency of hypoxanthine-guanine phosphoribosyltransferase with reduced affinity for PP-ribose-P in four related males with gout.

Pub. Date : 1984

PMID : 6204922






1 Functional Relationships(s)
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1 The affected males were found to have markedly reduced levels of erythrocytic hypoxanthine-guanine phosphoribosyltransferase (HGPRT) activity; these were 5-12% with hypoxanthine and 0.5-3% with guanine as compared to controls. Hypoxanthine hypoxanthine phosphoribosyltransferase 1 Homo sapiens