Title : Use of the HPRT gene and the HAT selection technique in DNA-mediated transformation of mammalian cells: first steps toward developing hybridoma techniques and gene therapy.

Pub. Date : 1992 Jul

PMID : 1445289






1 Functional Relationships(s)
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1 For instance, mutants resistant to azahypoxanthine showed a loss of the HPRT enzyme (hypoxanthine phosphoribosyl transferase), whereas gain of the same enzyme was accomplished by blocking de novo purine biosynthesis with aminopterin, while supplying hypoxanthine and thymine (HAT selection). Hypoxanthine hypoxanthine phosphoribosyltransferase 1 Homo sapiens