Lapatinib

erb-b2 receptor tyrosine kinase 2 ; Homo sapiens







1075 Article(s)
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1 34718243 Liquid Biopsy in Metastatic Breast Cancer: Current Role of Circulating Tumor Cells and Circulating Tumor DNA. 2022 3
2 34820552 Resetting amino acid metabolism of cancer cells by ATB0,+-targeted nanoparticles for enhanced anticancer therapy. 2022 Mar 1
3 34894465 The first reported case of trastuzumab induced interstitial lung disease associated with anti-neutrophil cytoplasmic antibody vasculitis - A case report and a prospective cohort study on the usefulness of neutrophil derived biomarkers in monitoring vasculitis disease activity during follow-up. 2022 Feb 1
4 34896211 IGF2BP2-dependent activation of ERBB2 signaling contributes to acquired resistance to tyrosine kinase inhibitor in differentiation therapy of radioiodine-refractory papillary thyroid cancer. 2022 Feb 28 1
5 34958115 Lysosome‑targeted drug combination induces multiple organelle dysfunctions and non‑canonical death in pancreatic cancer cells. 2022 Feb 1
6 35144424 The efficacy of pyrotinib-based therapy in lapatinib-resistant metastatic HER2-positive breast cancer. 2022 Jan 2
7 35158093 Phosphoproteome of signaling by ErbB2 in ovarian cancer cells. 2022 Apr 1 2
8 35159006 Prolyl Carboxypeptidase Maintains Receptor Tyrosine Kinase Signaling and Is a Potential Therapeutic Target in Triple Negative Breast Cancer. 2022 Jan 31 1
9 35177646 The significance of ErbB2/3 in the conversion of induced pluripotent stem cells into cancer stem cells. 2022 Feb 17 1
10 35248133 INHBA is a mediator of aggressive tumor behavior in HER2+ basal breast cancer. 2022 Mar 5 2
11 35270029 Glyceollins Trigger Anti-Proliferative Effects in Hormone-Dependent Aromatase-Inhibitor-Resistant Breast Cancer Cells through the Induction of Apoptosis. 2022 Mar 7 1
12 35276440 Survival after neoadjuvant therapy with trastuzumab-lapatinib and chemotherapy in patients with HER2-positive early breast cancer: a meta-analysis of randomized trials. 2022 Apr 1
13 35356262 Treatment with pyrotinib-based therapy in lapatinib-resistant HER2-positive metastatic breast cancer: a multicenter real-world study. 2022 2
14 35431974 Tyrosine Phosphatase PTPRO Deficiency in ERBB2-Positive Breast Cancer Contributes to Poor Prognosis and Lapatinib Resistance. 2022 2
15 35448925 [A real world study on the relationship between drug resistance of targeted therapy and prognosis of HER-2-positive advanced breast cancer]. 2022 Apr 23 1
16 35463361 Lapatinib Suppresses HER2-Overexpressed Cholangiocarcinoma and Overcomes ABCB1- Mediated Gemcitabine Chemoresistance. 2022 8
17 35503682 Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects. 2022 May 3 2
18 35549881 Targeting of ErbB1, ErbB2, and their Dual Targeting Using Small Molecules and Natural Peptides: Blocking EGFR Cell Signaling Pathways in Cancer: A Mini Review. 2022 May 12 1
19 35572995 Listeriosis in a Metropolitan Hospital: Is Targeted Therapy a Risk Factor for Infection? 2022 1
20 35617997 Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib. 2022 Jul 2
21 33085768 A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma. 2021 Mar 25 2
22 33122343 Effects of HER Family-targeting Tyrosine Kinase Inhibitors on Antibody-dependent Cell-mediated Cytotoxicity in HER2-expressing Breast Cancer. 2021 Feb 1 4
23 33150390 EGFR/ErbB2-Targeting Lapatinib Therapy for Aggressive Prolactinomas. 2021 Jan 23 1
24 33429148 CDK12 inhibition enhances sensitivity of HER2+ breast cancers to HER2-tyrosine kinase inhibitor via suppressing PI3K/AKT. 2021 Mar 4
25 33473169 Comparative analysis of drug response and gene profiling of HER2-targeted tyrosine kinase inhibitors. 2021 Mar 1
26 33514658 Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells. 2021 May 2
27 33559918 Effects of Ado-Trastuzumab Emtansine and Fam-Trastuzumab Deruxtecan on Metastatic Breast Cancer Harboring HER2 Amplification and the L755S Mutation. 2021 Aug 3
28 33569405 Pyrotinib versus trastuzumab emtansine for HER2-positive metastatic breast cancer after previous trastuzumab and lapatinib treatment: a real-world study. 2021 Jan 2
29 33652033 Qiliqiangxin alleviates Ang II-induced CMECs apoptosis by downregulating autophagy via the ErbB2-AKT-FoxO3a axis. 2021 May 15 1
30 33742063 Immune microenvironment characterisation and dynamics during anti-HER2-based neoadjuvant treatment in HER2-positive breast cancer. 2021 Mar 19 1
31 33755862 Personalized therapeutic strategies in HER2-driven gastric cancer. 2021 Jul 2
32 33785053 RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer. 2021 Mar 30 5
33 33801244 Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells. 2021 Mar 2 2
34 33842315 Discovery and Pharmacological Evaluation of STEAP4 as a Novel Target for HER2 Overexpressing Breast Cancer. 2021 2
35 33862249 Current treatment options for HER2-positive breast cancer patients with brain metastases. 2021 May 1
36 33907275 The role of HER2 and HER3 in HER2-amplified cancers beyond breast cancers. 2021 Apr 27 1
37 33919468 HER2-Targeted Immunotherapy and Combined Protocols Showed Promising Antiproliferative Effects in Feline Mammary Carcinoma Cell-Based Models. 2021 Apr 21 1
38 33933113 Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer. 2021 May 1 1
39 33936677 Dual HER2 blockade with lapatinib and trastuzumab in combination with chemotherapy in metastatic gastroesophageal adenocarcinoma. 2021 Apr 1
40 33939112 Identification of lysosome-targeting drugs with anti-inflammatory activity as potential invasion inhibitors of treatment resistant HER2 positive cancers. 2021 Aug 2
41 33951110 Clinical evaluation of BCL-2/XL levels pre- and post- HER2-targeted therapy. 2021 3
42 33980863 FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036. 2021 May 12 1
43 34016991 HER2-positive breast cancer and tyrosine kinase inhibitors: the time is now. 2021 May 20 1
44 34034468 [Application of neratinib in the treatment of hormone receptor and HER-2 double positive breast cancer]. 2021 May 23 1
45 34035375 MicroRNA in combination with HER2-targeting drugs reduces breast cancer cell viability in vitro. 2021 May 25 2
46 34045483 Neratinib plus trastuzumab is superior to pertuzumab plus trastuzumab in HER2-positive breast cancer xenograft models. 2021 May 27 1
47 34074257 Rac inhibition as a novel therapeutic strategy for EGFR/HER2 targeted therapy resistant breast cancer. 2021 Jun 1 1
48 34101105 HER3 PET Imaging Identifies Dynamic Changes in HER3 in Response to HER2 Inhibition with Lapatinib. 2021 Dec 3
49 34115243 Trastuzumab-induced cardiotoxicity: a review of clinical risk factors, pharmacologic prevention, and cardiotoxicity of other HER2-directed therapies. 2021 Jul 1
50 34126209 Lapatinib enhances paclitaxel toxicity in MCF-7, T47D, and MDA-MB-321 breast cancer cells. 2021 Sep 2