Title : Computational and Functional Analyses of HER2 Mutations Reveal Allosteric Activation Mechanisms and Altered Pharmacologic Effects.

Pub. Date : 2022 May 3

PMID : 35503682






2 Functional Relationships(s)
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1 Furthermore, HER2 allosteric mutants with enhanced covalent homodimerization were characterized by altered pharmacology that reduces the activity of existing anti-HER2 agents, including the monoclonal antibody trastuzumab and the tyrosine kinase inhibitor lapatinib. Lapatinib erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 Furthermore, HER2 allosteric mutants with enhanced covalent homodimerization were characterized by altered pharmacology that reduces the activity of existing anti-HER2 agents, including the monoclonal antibody trastuzumab and the tyrosine kinase inhibitor lapatinib. Lapatinib erb-b2 receptor tyrosine kinase 2 Homo sapiens