Title : Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells.

Pub. Date : 2021 May

PMID : 33514658






2 Functional Relationships(s)
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1 Neutralization of ERBB2 signaling with ERBB2 tyrosine kinase inhibitors (i.e., lapatinib, afatinib, and neratinib) increases apoptotic cell death and reduces human engraftment of MDS cells in mice at 21 weeks post-transplantation. Lapatinib erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 Neutralization of ERBB2 signaling with ERBB2 tyrosine kinase inhibitors (i.e., lapatinib, afatinib, and neratinib) increases apoptotic cell death and reduces human engraftment of MDS cells in mice at 21 weeks post-transplantation. Lapatinib erb-b2 receptor tyrosine kinase 2 Homo sapiens