Pub. Date : 2022
PMID : 35431974
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Despite the initial benefit from treating ERBB2-positive breast cancer with tyrosine kinase inhibitor lapatinib, resistance develops inevitably. | Lapatinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | Since the expression of protein tyrosine phosphatase receptor-type O (PTPRO), a member of the R3 subfamily of receptor protein tyrosine phosphatases (PTPs), is inversely correlated with the aggressiveness of multiple malignancies, we decided to explore the correlation between PTPRO and lapatinib resistance in ERBB2-positive breast cancer. | Lapatinib | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |