| 101 |
26178471 | D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2. | 2015 Jul 16 |
1 |
| 102 |
26280302 | Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. | 2015 Sep 10 |
2 |
| 103 |
26363012 | Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198. | 2015 Nov 15 |
3 |
| 104 |
26381180 | A high-sensitive HMab-2 specifically detects IDH1-R132H, the most common IDH mutation in gliomas. | 2015 Oct 30 |
5 |
| 105 |
26508549 | Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. | 2015 Dec 1 |
2 |
| 106 |
26590767 | IDH2 inhibition in AML: Finally progress? | 2015 Jun-Sep |
2 |
| 107 |
26686626 | Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. | 2015 Dec 22 |
2 |
| 108 |
24529257 | D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma. | 2014 Feb 14 |
2 |
| 109 |
24531386 | IDH1 p.R132 mutations may not be actively involved in the carcinogenesis of hepatocellular carcinoma. | 2014 Feb 14 |
1 |
| 110 |
24549719 | Lithium chloride decreases proliferation and migration of C6 glioma cells harboring isocitrate dehydrogenase 2 mutant via GSK-3β. | 2014 Jun |
1 |
| 111 |
24590270 | Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation. | 2014 Jun |
5 |
| 112 |
24668804 | Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1. | 2014 May 16 |
1 |
| 113 |
24675140 | Dimethyl α-ketoglutarate inhibits maladaptive autophagy in pressure overload-induced cardiomyopathy. | 2014 May |
1 |
| 114 |
24857658 | Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. | 2014 Jun 12 |
1 |
| 115 |
24880135 | The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation. | 2014 Dec |
1 |
| 116 |
24898068 | Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone. | 2014 Jun |
2 |
| 117 |
24980596 | Identification and Characterization of Small-Molecule Inhibitors of the R132H/R132H Mutant Isocitrate Dehydrogenase 1 Homodimer and R132H/Wild-Type Heterodimer. | 2014 Sep |
4 |
| 118 |
25271760 | Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. | 2014 Oct 23 |
1 |
| 119 |
25485496 | IDH mutations in liver cell plasticity and biliary cancer. | 2014 |
1 |
| 120 |
25502799 | Single arginine mutation in two yeast isocitrate dehydrogenases: biochemical characterization and functional implication. | 2014 |
2 |
| 121 |
22391558 | Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. | 2013 Jan 31 |
1 |
| 122 |
23107437 | Withaferin A suppresses tumor promoter 12-O-tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells. | 2013 Feb |
1 |
| 123 |
23232569 | Mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 in tumors. | 2013 Jan |
1 |
| 124 |
23504317 | Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle. | 2013 May 3 |
1 |
| 125 |
23507484 | Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies. | 2013 Jan |
1 |
| 126 |
23541771 | NADP+ -dependent IDH1 R132 mutation and its relevance for glioma patient survival. | 2013 Jun |
1 |
| 127 |
23630074 | What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. | 2013 Apr 15 |
1 |
| 128 |
23634848 | 5-hydroxymethylcytosine and its potential roles in development and cancer. | 2013 May 1 |
2 |
| 129 |
23731180 | Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism. | 2013 Jul 2 |
1 |
| 130 |
23795241 | Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. | 2013 Jun 13 |
1 |
| 131 |
23801081 | Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death. | 2013 Nov |
6 |
| 132 |
23847760 | The emerging role of d-2-hydroxyglutarate as an oncometabolite in hematolymphoid and central nervous system neoplasms. | 2013 |
6 |
| 133 |
23876293 | Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion. | 2013 Nov |
1 |
| 134 |
24019001 | Non-invasive in vivo assessment of IDH1 mutational status in glioma. | 2013 |
3 |
| 135 |
24077277 | An R132H mutation in isocitrate dehydrogenase 1 enhances p21 expression and inhibits phosphorylation of retinoblastoma protein in glioma cells. | 2013 |
6 |
| 136 |
24077805 | 5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft. | 2013 Oct |
2 |
| 137 |
22105553 | Mutations in isocitrate dehydrogenase 2 accelerate glioma cell migration via matrix metalloproteinase-2 and 9. | 2012 Mar |
1 |
| 138 |
22343901 | IDH mutation impairs histone demethylation and results in a block to cell differentiation. | 2012 Feb 15 |
2 |
| 139 |
22397365 | Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients. | 2012 Mar 7 |
1 |
| 140 |
22442146 | Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation. | 2012 Apr 27 |
2 |
| 141 |
22533343 | Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase. | 2012 Aug |
2 |
| 142 |
22675360 | The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells. | 2012 |
1 |
| 143 |
22772731 | IDH1 mutations inhibit multiple α-ketoglutarate-dependent dioxygenase activities in astroglioma. | 2012 Sep |
1 |
| 144 |
23071358 | IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives. | 2012 Oct 15 |
1 |
| 145 |
21251613 | Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. | 2011 Jan 18 |
1 |
| 146 |
21625441 | Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma. | 2011 |
1 |
| 147 |
21641335 | Glioma-derived mutations in isocitrate dehydrogenase 2 beneficial to traditional chemotherapy. | 2011 Jul 1 |
2 |
| 148 |
21690245 | TET2 promoter methylation in low-grade diffuse gliomas lacking IDH1/2 mutations. | 2011 Oct |
1 |
| 149 |
21885076 | Metabolism of glioma and IDH1/IDH2 mutations. | 2011 Oct |
2 |
| 150 |
21889589 | A lymphoblast model for IDH2 gain-of-function activity in d-2-hydroxyglutaric aciduria type II: novel avenues for biochemical and therapeutic studies. | 2011 Nov |
1 |