Title : Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1.

Pub. Date : 2015 Dec 1

PMID : 26508549






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 We have observed that alpha-mangostin competitively inhibits the binding of alpha-ketoglutarate (alpha-KG) to IDH1-R132H. Ketoglutaric Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 We have observed that alpha-mangostin competitively inhibits the binding of alpha-ketoglutarate (alpha-KG) to IDH1-R132H. Ketoglutaric Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens