Title : A high-sensitive HMab-2 specifically detects IDH1-R132H, the most common IDH mutation in gliomas.

Pub. Date : 2015 Oct 30

PMID : 26381180






5 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Although IDH1 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in cytosol, mutated IDH1 proteins possess the ability to change alpha-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG). Ketoglutaric Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 Although IDH1 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in cytosol, mutated IDH1 proteins possess the ability to change alpha-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG). Ketoglutaric Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
3 Although IDH1 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in cytosol, mutated IDH1 proteins possess the ability to change alpha-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG). Ketoglutaric Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
4 Although IDH1 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in cytosol, mutated IDH1 proteins possess the ability to change alpha-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG). Ketoglutaric Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
5 Although IDH1 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in cytosol, mutated IDH1 proteins possess the ability to change alpha-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG). Ketoglutaric Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens