Rac family small GTPase 2 ; Homo sapiens






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1 1316893 Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins. J Biol Chem 1992 May 25 2
2 1328203 Inhibition of superoxide production in B lymphocytes by rac antisense oligonucleotides. J Biol Chem 1992 Oct 15 3
3 1331090 Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase. J Biol Chem 1992 Nov 25 3
4 1464587 Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase. J Biol Chem 1992 Dec 25 9
5 1660188 Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 1991 Dec 6 3
6 1903399 Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA. J Biol Chem 1991 May 25 7
7 2111992 A small GTP-binding protein (G protein) recognized by smg p25A GDP dissociation inhibitor (GDI) in human platelet membranes and GDI for this small G protein in human platelet cytosol. Biochem Biophys Res Commun 1990 May 16 1
8 2119580 Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization. Biochem Biophys Res Commun 1990 Sep 14 5
9 2674130 rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem 1989 Oct 5 2
10 7475908 Identification of heterotrimeric GTP-binding proteins in human megakaryoblastic leukemia cell line, MEG-01, and their alteration during cellular differentiation. Life Sci 1995 2
11 7479768 Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc Natl Acad Sci U S A 1995 Oct 24 2
12 7513523 Assembly and regulation of NADPH oxidase and nitric oxide synthase. Curr Opin Immunol 1994 Feb 2
13 7616102 Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors. J Leukoc Biol 1995 Jul 1
14 7654216 The assembly of neutrophil NADPH oxidase: effects of mastoparan and its synthetic analogues. Biochem J 1995 Sep 1 1
15 7696531 A comparative study of meso- and rac-2,3-dimercaptosuccinic acids and their zinc complexes in aqueous solution. Chem Res Toxicol 1994 Nov-Dec 5
16 7696547 Conformations of zinc chelates of meso- and rac-2,3-dimercaptosuccinic acid in aqueous solution. Chem Res Toxicol 1994 Nov-Dec 20
17 7744791 Translocation of p21rac2 from cytosol to plasma membrane is neither necessary nor sufficient for neutrophil NADPH oxidase activity. J Biol Chem 1995 May 12 1
18 7833480 Function of wild-type or mutant Rac2 and Rap1a GTPases in differentiated HL60 cell NADPH oxidase activation. Blood 1995 Feb 1 2
19 7852400 Low molecular weight GTP-binding proteins in HL-60 granulocytes. Assessment of the role of ARF and of a 50-kDa cytosolic protein in phospholipase D activation. J Biol Chem 1995 Feb 17 2
20 7980444 SmgGDS stabilizes nucleotide-bound and -free forms of the Rac1 GTP-binding protein and stimulates GTP/GDP exchange through a substituted enzyme mechanism. Biochem J 1994 Nov 1 3
21 8071333 p67-phox enhances the binding of p47-phox to the human neutrophil respiratory burst oxidase complex. J Biol Chem 1994 Sep 2 1
22 8089125 Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac. J Biol Chem 1994 Sep 23 5
23 8117279 The small GTP-binding protein rac is not recruited to the plasma membrane upon NADPH oxidase activation in human neutrophils. Biochem Biophys Res Commun 1994 Feb 15 1
24 8117710 p21rac does not participate in the early interaction between p47-phox and cytochrome b558 that leads to phagocyte NADPH oxidase activation in vitro. Biochemistry 1994 Mar 8 1
25 8120032 Cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase. Transfer of Rac2 and the cytosolic oxidase components p47phox and p67phox to the submembranous actin cytoskeleton during oxidase activation. J Biol Chem 1994 Mar 4 1
26 8141770 Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane. Biochem J 1994 Mar 15 6
27 8199302 Synthesis, structure, and properties of rac-2,3-dimercaptosuccinic acid, a potentially useful chelating agent for toxic metals. Chem Res Toxicol 1994 Mar-Apr 5
28 8282094 Regulation of phagocyte function by low molecular weight GTP-binding proteins. Eur J Haematol 1993 Nov 3
29 8305740 Regulation of NADPH oxidase activity by Rac GTPase activating protein(s). Mol Biol Cell 1993 Nov 4
30 8387355 Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase. Mol Biol Cell 1993 Mar 4
31 8621595 Enhancement of protein kinase C-dependent O2 production in Epstein-Barr virus-transformed B lymphocytes by p120Ras-GAP antisense oligonucleotide. J Biol Chem 1996 Apr 19 1
32 8645270 Translocation of p190rho guanosine triphosphatase-activating protein from cytosol to the membrane in human neutrophils stimulated with different agonists. Biochem Biophys Res Commun 1996 Feb 27 2
33 8663333 Assembly of the human neutrophil NADPH oxidase involves binding of p67phox and flavocytochrome b to a common functional domain in p47phox. J Biol Chem 1996 Jul 19 1
34 8670049 Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox. Biochem J 1996 Mar 1 1
35 8824295 Fas-induced apoptosis is mediated by activation of a Ras and Rac protein-regulated signaling pathway. J Biol Chem 1996 Oct 18 1
36 8961931 Membrane association of Rac is required for high activity of the respiratory burst oxidase. Biochemistry 1996 Dec 10 1
37 8986819 L-selectin activates the Ras pathway via the tyrosine kinase p56lck. Proc Natl Acad Sci U S A 1996 Dec 24 1
38 9012677 Guanine nucleotide binding properties of Rac2 mutant proteins and analysis of the responsiveness to guanine nucleotide dissociation stimulator. Biochemistry 1997 Jan 21 4
39 9157598 Differential expression of low Mr GTP-binding proteins in human megakaryoblastic leukemia cell line, MEG-01, and their possible involvement in the differentiation process. Thromb Haemost 1997 Feb 1
40 9228059 Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidase. J Biol Chem 1997 Jul 25 2
41 9252344 Characterization of RAC3, a novel member of the Rho family. J Biol Chem 1997 Aug 15 1
42 9255350 [Signal transduction by Rac small G proteins in phagocytes]. C R Seances Soc Biol Fil 1997 1
43 9343750 A rise in ionized calcium activates the neutrophil NADPH-oxidase but is not sufficient to directly translocate cytosolic p47phox or p67phox to b cytochrome containing membranes. Inflammation 1997 Oct 1
44 9624165 Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox). J Biol Chem 1998 Jun 19 2
45 9705280 Structural requirements for PAK activation by Rac GTPases. J Biol Chem 1998 Aug 21 3
46 9748241 Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation. J Biol Chem 1998 Oct 2 1
47 9873447 A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P3 and its effect on Cl(-)-secretion from T84 cells. Bioorg Med Chem Lett 1998 Jul 21 3
48 10231020 Cysteine carboxyl O-methylation of human placental 23 kDa protein. Exp Mol Med 1999 Mar 31 1
49 10364257 Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils. J Biol Chem 1999 Jun 18 6
50 10381206 Inhibition of GTP binding to Rac2 by peroxynitrite: potential role for tyrosine modification. Free Radic Biol Med 1999 May 15