Title : Guanine nucleotide binding properties of Rac2 mutant proteins and analysis of the responsiveness to guanine nucleotide dissociation stimulator.

Pub. Date : 1997 Jan 21

PMID : 9012677






4 Functional Relationships(s)
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1 Guanine nucleotide binding properties of Rac2 mutant proteins and analysis of the responsiveness to guanine nucleotide dissociation stimulator. Guanine Nucleotides Rac family small GTPase 2 Homo sapiens
2 We have generated and purified such Rac2 mutants and characterized their guanine nucleotide binding properties in vitro. Guanine Nucleotides Rac family small GTPase 2 Homo sapiens
3 The Rac2 G12V and Q61L activating mutations were shown to hydrolyze bound GTP very slowly and were unresponsive to p190 Rac GTPase-activating protein. Guanosine Triphosphate Rac family small GTPase 2 Homo sapiens
4 We show that guanine nucleotide exchange by smgGDS is dependent upon intact switch 1 and switch 2 regions in Rac2. Guanine Nucleotides Rac family small GTPase 2 Homo sapiens