protein phosphatase 1 regulatory subunit 12A ; Homo sapiens






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1 9200713 Interaction of smooth muscle myosin phosphatase with phospholipids. Biochemistry 1997 Jun 17 2
2 10530875 Effects of the phosphorylation of myosin phosphatase by cyclic GMP-dependent protein kinase. Cell Signal 1999 Sep 1
3 10570971 Identification and characterization of Drosophila homolog of Rho-kinase. Gene 1999 Oct 1 1
4 11068043 Phosphorylation of MYPT1 by protein kinase C attenuates interaction with PP1 catalytic subunit and the 20 kDa light chain of myosin. FEBS Lett 2000 Nov 3 1
5 11486008 Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation. J Biol Chem 2001 Oct 5 3
6 11931630 Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton. Biochem J 2002 Jul 1 4
7 11943207 Dephosphorylation of the two regulatory components of myosin phosphatase, MBS and CPI17. FEBS Lett 2002 Mar 27 2
8 12030846 Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. Biochem J 2002 Aug 15 1
9 14709404 Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res 2004 Jan 5
10 15194681 Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. J Biol Chem 2004 Aug 13 5
11 15226371 Disruption of Rho signal transduction upon cell detachment. J Cell Sci 2004 Jul 15 2
12 15281089 Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol 2004 Oct 5
13 15665049 Alpha1-adrenoceptor-mediated phosphorylation of MYPT-1 and CPI-17 in the uterine artery: role of ERK/PKC. Am J Physiol Heart Circ Physiol 2005 Jun 5
14 16038801 Okadaic acid induces phosphorylation and translocation of myosin phosphatase target subunit 1 influencing myosin phosphorylation, stress fiber assembly and cell migration in HepG2 cells. Cell Signal 2005 Oct 6
15 16257966 M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells. J Biol Chem 2005 Dec 30 1
16 16356512 Myosin phosphatase isoform switching in vascular smooth muscle development. J Mol Cell Cardiol 2006 Feb 1
17 16439434 Ca2+-desensitizing hypoxic vasorelaxation: pivotal role for the myosin binding subunit of myosin phosphatase (MYPT1) in porcine coronary artery. J Physiol 2006 Apr 1 1
18 16554414 Expression of RND proteins in human myometrium. Biol Reprod 2006 Sep 1
19 16608882 Agonist- and depolarization-induced signals for myosin light chain phosphorylation and force generation of cultured vascular smooth muscle cells. J Cell Sci 2006 May 1 1
20 16923126 Ca2+ -independent phospholipase A2-dependent sustained Rho-kinase activation exhibits all-or-none response. Genes Cells 2006 Sep 1
21 17105828 Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation. J Pharmacol Exp Ther 2007 Feb 1
22 17179444 Essential role for class II phosphoinositide 3-kinase alpha-isoform in Ca2+-induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells. Mol Pharmacol 2007 Mar 2
23 17293476 Conditioning effect of blood flow on resistance artery smooth muscle myosin phosphatase. Circ Res 2007 Mar 16 1
24 17301291 Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor. Biol Reprod 2007 Jun 6
25 17408601 Extracellular ATP induces assembly and activation of the myosin light chain phosphatase complex in endothelial cells. Cardiovasc Res 2007 Jun 1 5
26 18079119 Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor. J Biol Chem 2008 Feb 8 1
27 18094049 A novel regulatory mechanism of myosin light chain phosphorylation via binding of 14-3-3 to myosin phosphatase. Mol Biol Cell 2008 Mar 1
28 18237278 G(q)-dependent signalling by the lysophosphatidic acid receptor LPA(3) in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA. Biochem J 2008 May 1 10
29 18423375 Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cells. Biochem Biophys Res Commun 2008 Jun 20 6
30 18599801 Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK. Arterioscler Thromb Vasc Biol 2008 Oct 3
31 18648664 Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma. PLoS One 2008 Jul 23 1
32 18755268 Myosin phosphatase interacts with and dephosphorylates the retinoblastoma protein in THP-1 leukemic cells: its inhibition is involved in the attenuation of daunorubicin-induced cell death by calyculin-A. Cell Signal 2008 Nov 2
33 18776185 Apolipoprotein(a), through its strong lysine-binding site in KIV(10'), mediates increased endothelial cell contraction and permeability via a Rho/Rho kinase/MYPT1-dependent pathway. J Biol Chem 2008 Nov 7 1
34 18991642 RhoA/Rho-kinase as a therapeutic target in asthma. Curr Med Chem 2008 6
35 19095646 Thromboxane A2-induced bi-directional regulation of cerebral arterial tone. J Biol Chem 2009 Mar 6 10
36 19107880 The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA/Rho kinase and NF-kappaB pathways. Prostate 2009 Apr 1 2
37 19120700 The potential role of MLC phosphatase and MAPK signalling in the pathogenesis of vascular dysfunction in heart failure. J Cell Mol Med 2008 Dec 2
38 19245366 MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). Biochem J 2009 May 13 1
39 19277501 Inhibitory effect of genistein on agonist-induced modulation of vascular contractility. Mol Cells 2009 Feb 28 3
40 19531490 Phosphorylation-dependent autoinhibition of myosin light chain phosphatase accounts for Ca2+ sensitization force of smooth muscle contraction. J Biol Chem 2009 Aug 7 11
41 19879105 The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells. Biomed Pharmacother 2010 Jan 4
42 19939965 Degradation of leucine zipper-positive isoform of MYPT1 may contribute to development of nitrate tolerance. Cardiovasc Res 2010 Apr 1 2
43 20037178 Proteomics analysis of the cardiac myofilament subproteome reveals dynamic alterations in phosphatase subunit distribution. Mol Cell Proteomics 2010 Mar 1
44 20354225 New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci Signal 2010 Mar 30 10
45 20418385 Increased degradation of MYPT1 contributes to the development of tolerance to nitric oxide in porcine pulmonary artery. Am J Physiol Lung Cell Mol Physiol 2010 Jul 13
46 20634291 Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. J Biol Chem 2010 Sep 17 1
47 20801872 Heart-specific small subunit of myosin light chain phosphatase activates rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1. J Biol Chem 2010 Oct 29 4
48 21115810 Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. Cancer Res 2011 Feb 1 2
49 21252232 Myosin phosphatase-targeting subunit 1 controls chromatid segregation. J Biol Chem 2011 Mar 25 2
50 21397262 Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate the spastic radial artery during coronary artery bypass grafting surgery. J Thorac Cardiovasc Surg 2011 Aug 2