Title : Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.

Pub. Date : 2011 Feb 1

PMID : 21115810






2 Functional Relationships(s)
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1 We found that MYPT1 was methylated in vitro and in vivo by histone lysine methyltransferase SETD7 and demethylated by LSD1, identifying Lys 442 of MYPT1 as a target for methylation/demethylation by these enzymes. Lysine protein phosphatase 1 regulatory subunit 12A Homo sapiens
2 We found that MYPT1 was methylated in vitro and in vivo by histone lysine methyltransferase SETD7 and demethylated by LSD1, identifying Lys 442 of MYPT1 as a target for methylation/demethylation by these enzymes. Lysine protein phosphatase 1 regulatory subunit 12A Homo sapiens