Title : Essential role for class II phosphoinositide 3-kinase alpha-isoform in Ca2+-induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells.

Pub. Date : 2007 Mar

PMID : 17179444






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Ionomycin induced phosphorylation of the MLCP-regulatory subunit myosin targeting protein 1(MYPT1) at Thr850 and the 20-kDa myosin light chain (MLC) in a Rho kinase-dependent manner. Ionomycin protein phosphatase 1 regulatory subunit 12A Homo sapiens
2 The receptor agonist noradrenaline, which induced a rapid increase in the [Ca2+]i and Ca2+-dependent contraction, stimulated phosphorylation of MYPT1 and MLC, which was also dependent on Ca2+, PI3K-C2alpha, and Rho-kinase. Norepinephrine protein phosphatase 1 regulatory subunit 12A Homo sapiens