urocortin ; Homo sapiens






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51 14576187 Corticotropin-releasing hormone and its structurally related urocortin are synthesized and secreted by human mast cells. Endocrinology 2004 Jan 1
52 14645003 Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells. Blood 2004 Apr 1 2
53 14645670 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL. Mol Pharmacol 2003 Dec 2
54 14657255 Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity. Mol Endocrinol 2004 Mar 3
55 14960712 Biochemical characterization of the mitochondrial tRNASer(UCN) T7511C mutation associated with nonsyndromic deafness. Nucleic Acids Res 2004 1
56 15210164 Sporadic mitochondrial myopathy due to a new mutation in the mitochondrial tRNASer(UCN) gene. Neuromuscul Disord 2004 Jul 2
57 15467762 The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein. Oncogene 2005 Jan 6 1
58 15476942 Urocortins in human reproduction. Peptides 2004 Oct 1
59 15482956 Monomelic amyotrophy associated with the 7472insC mutation in the mtDNA tRNASer(UCN) gene. Neuromuscul Disord 2004 Nov 1
60 15571286 Combinations of 5-fluorouracil with UCN-01 or staurosporine. Nucleosides Nucleotides Nucleic Acids 2004 Oct 1
61 15694374 Biochemical characterization of the deafness-associated mitochondrial tRNASer(UCN) A7445G mutation in osteosarcoma cell cybrids. Biochem Biophys Res Commun 2005 Mar 11 3
62 15721872 Urocortin-induced relaxation in the human internal mammary artery. Cardiovasc Res 2005 Mar 1 11
63 15782134 Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints. Oncogene 2005 May 26 1
64 15784708 Preeclampsia is associated with impaired regulation of the placental nitric oxide-cyclic guanosine monophosphate pathway by corticotropin-releasing hormone (CRH) and CRH-related peptides. J Clin Endocrinol Metab 2005 Jun 1
65 15805289 RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells. Cancer Res 2005 Apr 1 1
66 15958629 The cyclin-dependent kinase inhibitor UCN-01 plus cisplatin in advanced solid tumors: a California cancer consortium phase I pharmacokinetic and molecular correlative trial. Clin Cancer Res 2005 Jun 15 3
67 15958645 The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells. Clin Cancer Res 2005 Jun 15 2
68 16133542 Late-onset mitochondrial myopathy with dystrophic changes due to a G7497A mutation in the mitochondrial tRNA(Ser(UCN)) gene. Acta Neuropathol 2005 Oct 2
69 16152638 Cosegregation of the G7444A mutation in the mitochondrial COI/tRNA(Ser(UCN)) genes with the 12S rRNA A1555G mutation in a Chinese family with aminoglycoside-induced and nonsyndromic hearing loss. Am J Med Genet A 2005 Oct 1 1
70 16199753 A new mechanism for mtDNA pathogenesis: impairment of post-transcriptional maturation leads to severe depletion of mitochondrial tRNASer(UCN) caused by T7512C and G7497A point mutations. Nucleic Acids Res 2005 2
71 16300406 Photoaffinity cross-linking of the corticotropin-releasing factor receptor type 1 with photoreactive urocortin analogues. Biochemistry 2005 Nov 29 4
72 16340217 Endothelial urocortin has potent antioxidative properties and is upregulated by inflammatory cytokines and pitavastatin. J Vasc Res 2006 2
73 16500624 Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNASer(UCN) genes in two Chinese families. Biochem Biophys Res Commun 2006 Apr 14 1
74 16604644 Activation calculations for the target of a spallation ultra-cold neutron source at PSI. Radiat Prot Dosimetry 2005 1
75 16672665 Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene. J Neurosci 2006 May 3 1
76 16698078 Expression of urocortin in the extravillous human trophoblast at the implantation site. Placenta 2007 Feb-Mar 12
77 16759460 [Level of urocortin mRNA during labor and effect of urocortin on myometrial contractility in vitro]. Zhonghua Fu Chan Ke Za Zhi 2006 Apr 1
78 16920724 Secretory endometrium highly expresses urocortin messenger RNA and peptide: possible role in the decidualization process. Hum Reprod 2007 Jan 5
79 17194738 Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner. Endocrinology 2007 Apr 1
80 17264303 Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation. Blood 2007 May 15 5
81 17326013 Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands. Horm Metab Res 2007 Feb 1
82 17533422 Achieving signalling selectivity of ligands for the corticotropin-releasing factor type 1 receptor by modifying the agonist's signalling domain. Br J Pharmacol 2007 Jul 1
83 17537491 UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: a study of the Princess Margaret Hospital Phase II consortium. Gynecol Oncol 2007 Aug 1
84 17540843 MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism. Blood 2007 Sep 15 3
85 17614276 A novel heteroplasmic tRNA(Ser(UCN)) mtDNA point mutation associated with progressive external ophthalmoplegia and hearing loss. Neuromuscul Disord 2007 Oct 1
86 17659260 Mitochondrial tRNASer(UCN) gene is the hot spot for mutations associated with aminoglycoside-induced and non-syndromic hearing loss. Biochem Biophys Res Commun 2007 Sep 14 1
87 18347148 Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo. Mol Cancer Ther 2008 Mar 8
88 18537605 Phenotypic variants of the deafness-associated mitochondrial DNA A7445G mutation. Curr Med Chem 2008 2
89 19026699 Possible involvement of corticotropin-releasing factor receptor signaling on vascular inflammation. Peptides 2009 Feb 1
90 19318426 Regulation of urocortin I and its related peptide urocortin II by inflammatory and oxidative stresses in HL-1 cardiomyocytes. J Mol Endocrinol 2009 Jun 3
91 19406492 Mechanisms of action and clinical implications of cardiac urocortin: a journey from the heart to the systemic circulation, with a stopover in the mitochondria. Int J Cardiol 2009 Nov 12 1
92 19768521 Detection of D-amino acids in purified proteins synthesized in Escherichia coli. Amino Acids 2010 May 1
93 19808377 Plasma urocortin 1 in human heart failure. Circ Heart Fail 2009 Sep 1
94 19949969 Differentiation dependent expression of urocortin's mRNA and peptide in human osteoprogenitor cells: influence of BMP-2, TGF-beta-1 and dexamethasone. J Mol Histol 2009 Oct 4
95 20153673 Maternally inherited hearing loss is associated with the novel mitochondrial tRNA Ser(UCN) 7505T>C mutation in a Han Chinese family. Mol Genet Metab 2010 May 1
96 20480172 The value of urocortin and Ca-125 in the diagnosis of endometrioma. Arch Gynecol Obstet 2011 May 1
97 20599444 Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells. Biochim Biophys Acta 2010 Oct 2
98 20833230 Ovarian steroid regulation of the midbrain corticotropin releasing factor and urocortin systems in macaques. Neuroscience 2010 Dec 15 1
99 21073883 Pathogenic mutations in antisense mitochondrial tRNAs. J Theor Biol 2011 Jan 21 1
100 21123435 Activation of Type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells: an enterochromaffin cell model. Endocrinology 2011 Jan 3