N(1),N(11)-diethylnorspermine






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1 2065327 Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines. Cancer Res 1991 Jul 15 1
2 2334396 Induction of spermidine/spermine N1-acetyltransferase activity in Chinese-hamster ovary cells by N1N11-bis(ethyl)norspermine (corrected) and related compounds. Biochem J 1990 Apr 15 1
3 7954423 Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine. Cancer Res 1994 Nov 15 1
4 8573111 Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells. Biochem J 1996 Jan 15 1
5 8818232 Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase. Bioorg Med Chem 1996 Jun 2
6 8916930 Effects of polyamines, polyamine analogs, and inhibitors of protein synthesis on spermidine-spermine N1-acetyltransferase gene expression. Biochemistry 1996 Nov 12 3
7 8917345 Sequence specific antisense oligonucleotide analog interference with spermidine/spermine N1-acetyltransferase gene expression. Anticancer Res 1996 Sep-Oct 4
8 9632528 Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines. Cytokine 1998 Jun 1
9 10024505 Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue. Biochem J 1999 Mar 1 1
10 10096560 Polyamine analogue induction of the p53-p21WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells. Cancer Res 1999 Mar 15 3
11 10430062 The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine. Clin Cancer Res 1999 Jul 3
12 10649978 Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives. J Med Chem 2000 Jan 27 1
13 10880565 Activation of polyamine catabolism in transgenic rats induces acute pancreatitis. Proc Natl Acad Sci U S A 2000 Jul 18 1
14 10978316 Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs. J Biol Chem 2000 Dec 8 1
15 11829751 Polyamines are required for the initiation of rat liver regeneration. Biochem J 2002 Feb 15 1
16 11846806 Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine. Eur J Biochem 2002 Feb 2
17 12578836 Properties of the spermidine/spermine N1-acetyltransferase mutant L156F that decreases cellular sensitivity to the polyamine analogue N1, N11-bis(ethyl)norspermine. J Biol Chem 2003 Apr 18 1
18 12827295 Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. Cancer Chemother Pharmacol 2003 Nov 2
19 12902979 Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells. Oncogene 2003 Aug 7 2
20 14573765 Small interfering RNA suppression of polyamine analog-induced spermidine/spermine n1-acetyltransferase. Mol Pharmacol 2003 Nov 2
21 15252142 Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase. Mol Cancer Ther 2004 Jul 4
22 16455797 Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Proc Natl Acad Sci U S A 2006 Feb 14 1
23 17237273 The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells. Mol Cancer Ther 2007 Jan 2
24 17690107 Polyamine-dependent regulation of spermidine-spermine N1-acetyltransferase mRNA translation. J Biol Chem 2007 Sep 28 1
25 17920945 Subcellular distribution of spermidine/spermine N1-acetyltransferase. Cell Biol Int 2008 Jan 2
26 17921698 Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells. Cancer Biol Ther 2007 Oct 2
27 17987291 Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine. Cancer Chemother Pharmacol 2008 Aug 2
28 19956992 Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis. Amino Acids 2010 Feb 2
29 20433143 Biogenic and synthetic polyamines bind bovine serum albumin. Biomacromolecules 2010 Jun 14 1
30 21506109 Sulforaphane protects human chondrocytes against cell death induced by various stimuli. J Cell Physiol 2011 Jul 1
31 21814790 Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells. Amino Acids 2012 Feb 2
32 22179681 Overexpression of SSAT by DENSPM treatment induces cell detachment and apoptosis in glioblastoma. Oncol Rep 2012 Apr 2
33 22545813 Synthesis of bisethylnorspermine lipid prodrug as gene delivery vector targeting polyamine metabolism in breast cancer. Mol Pharm 2012 Jun 4 1
34 29533973 Cellular and Animal Model Studies on the Growth Inhibitory Effects of Polyamine Analogues on Breast Cancer. Med Sci (Basel) 2018 Mar 13 3
35 29715464 Spermidine/spermine N1-acetyltransferase-mediated polyamine catabolism regulates beige adipocyte biogenesis. Metabolism 2018 Aug 3
36 29729200 Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features. Allergy 2018 Oct 3
37 31592495 Tumor-Selective Altered Glycosylation and Functional Attenuation of CD73 in Human Hepatocellular Carcinoma. Hepatol Commun 2019 Oct 3
38 31973848 Effects of intersubunit amino acid substitutions on GABA receptor sensitivity to the ectoparasiticide fluralaner. Pestic Biochem Physiol 2020 Feb 1