Title : Tumor-Selective Altered Glycosylation and Functional Attenuation of CD73 in Human Hepatocellular Carcinoma.

Pub. Date : 2019 Oct

PMID : 31592495






3 Functional Relationships(s)
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1 Biochemically, tumor-associated CD73 was deficient in hybrid and complex glycans specifically on residues N311 and N333 located in the C-terminal catalytic domain. N(1),N(11)-diethylnorspermine 5'-nucleotidase ecto Homo sapiens
2 Blocking N311/N333 glycosylation by site-directed mutagenesis produced CD73 with significantly decreased 5"-nucleotidase activity in vitro, similar to the primary tumors. N(1),N(11)-diethylnorspermine 5'-nucleotidase ecto Homo sapiens
3 Blocking N311/N333 glycosylation by site-directed mutagenesis produced CD73 with significantly decreased 5"-nucleotidase activity in vitro, similar to the primary tumors. N(1),N(11)-diethylnorspermine 5'-nucleotidase ecto Homo sapiens