Title : Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features.

Pub. Date : 2018 Oct

PMID : 29729200






3 Functional Relationships(s)
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1 Similarly, while pharmacological induction of SAT1 and SMOX using the polyamine analogue bis(ethyl)norspermine (BENSPM) alleviated asthmatic features with reduced TSLP levels and BEC apoptosis, pharmacological inhibition of these enzymes using BERENIL or MDL72527, respectively, worsened them. N(1),N(11)-diethylnorspermine spermidine/spermine N1-acetyl transferase 1 Mus musculus
2 Similarly, while pharmacological induction of SAT1 and SMOX using the polyamine analogue bis(ethyl)norspermine (BENSPM) alleviated asthmatic features with reduced TSLP levels and BEC apoptosis, pharmacological inhibition of these enzymes using BERENIL or MDL72527, respectively, worsened them. N(1),N(11)-diethylnorspermine spermine oxidase Mus musculus
3 Similarly, while pharmacological induction of SAT1 and SMOX using the polyamine analogue bis(ethyl)norspermine (BENSPM) alleviated asthmatic features with reduced TSLP levels and BEC apoptosis, pharmacological inhibition of these enzymes using BERENIL or MDL72527, respectively, worsened them. N(1),N(11)-diethylnorspermine thymic stromal lymphopoietin Mus musculus