Pub. Date : 2021 Nov
PMID : 34435315
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Trelagliptin is a DPP-4 inhibitor applied for the treatment of type II diabetes and has been recently reported to exert various pharmacological properties. | trelagliptin | dipeptidyl peptidase 4 | Homo sapiens |
| 2 | In addition, the declined mitochondrial respiration and ATP production decreased secretion of cystathionine and creatine, and the increased production of triglyceride and adiponectin in OGD/R-challenged HAVECs was dramatically reversed by Trelagliptin, accompanied by the upregulated expression level of PGC-1alpha and CPT-1. | trelagliptin | adiponectin, C1Q and collagen domain containing | Homo sapiens |
| 3 | In addition, the declined mitochondrial respiration and ATP production decreased secretion of cystathionine and creatine, and the increased production of triglyceride and adiponectin in OGD/R-challenged HAVECs was dramatically reversed by Trelagliptin, accompanied by the upregulated expression level of PGC-1alpha and CPT-1. | trelagliptin | PPARG coactivator 1 alpha | Homo sapiens |
| 4 | In addition, the declined mitochondrial respiration and ATP production decreased secretion of cystathionine and creatine, and the increased production of triglyceride and adiponectin in OGD/R-challenged HAVECs was dramatically reversed by Trelagliptin, accompanied by the upregulated expression level of PGC-1alpha and CPT-1. | trelagliptin | carnitine palmitoyltransferase 1A | Homo sapiens |
| 5 | Lastly, the AMPK pathway was observed to be significantly activated in OGD/R-challenged HAVECs by Trelagliptin treatment. | trelagliptin | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 6 | After co-administration of the inhibitor of the AMPK pathway, the effects of Trelagliptin on mitochondrial function and metabolic alterations were significantly abolished. | trelagliptin | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 7 | Taken together, our data indicate that Trelagliptin ameliorated OGD/R-induced mitochondrial disturbance and metabolic changes by activating the AMPK pathway. | trelagliptin | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |