Protein Name PPARG coactivator 1 alpha
Organism Homo sapiens
Gene ID 10891
Gene Symbol


UniProt Q9UBK2 (PRGC1_HUMAN), A0A024R9Q9 (A0A024R9Q9_HUMAN)
Relationships Total Number of functionally related compound(s) : 580
Total Number of Articles : 1096

PPARG coactivator 1 alpha

Gene Summary

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

  • peroxisome proliferator-activated receptor gamma coactivator 1-alpha
  • L-PGC-1alpha
  • PGC-1-alpha
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