Title : CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action.

Pub. Date : 2020 Jul

PMID : 32459381






8 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CUDC-907-induced apoptosis was partially dependent on Mcl-1, Bcl-xL, Bim and c-Myc. CUDC-907 MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 CUDC-907-induced apoptosis was partially dependent on Mcl-1, Bcl-xL, Bim and c-Myc. CUDC-907 BCL2 like 1 Homo sapiens
3 CUDC-907-induced apoptosis was partially dependent on Mcl-1, Bcl-xL, Bim and c-Myc. CUDC-907 BCL2 like 11 Homo sapiens
4 CUDC-907-induced apoptosis was partially dependent on Mcl-1, Bcl-xL, Bim and c-Myc. CUDC-907 MYC proto-oncogene, bHLH transcription factor Homo sapiens
5 Further, down-regulation of Wee1, CHK1, RRM1 and RRM2 contributed to CUDC-907-induced DNA damage and apoptosis. CUDC-907 WEE1 G2 checkpoint kinase Homo sapiens
6 Further, down-regulation of Wee1, CHK1, RRM1 and RRM2 contributed to CUDC-907-induced DNA damage and apoptosis. CUDC-907 checkpoint kinase 1 Homo sapiens
7 Further, down-regulation of Wee1, CHK1, RRM1 and RRM2 contributed to CUDC-907-induced DNA damage and apoptosis. CUDC-907 ribonucleotide reductase catalytic subunit M1 Homo sapiens
8 Further, down-regulation of Wee1, CHK1, RRM1 and RRM2 contributed to CUDC-907-induced DNA damage and apoptosis. CUDC-907 ribonucleotide reductase regulatory subunit M2 Homo sapiens