Title : Geraniol activates Nrf-2/HO-1 signaling pathway mediating protection against oxidative stress-induced apoptosis in hepatic ischemia-reperfusion injury.

Pub. Date : 2020 Oct

PMID : 32417955






7 Functional Relationships(s)
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1 To detect GOH effect against liver IRI through the activation of the Nrf2/HO-1 antioxidant pathway, five groups of rats were randomized to normal, sham, IR, GOH, and GOH/IR. 5-[2-Cyclopropyl-5-(1h-Pyrrol-1-Yl)-1,3-Oxazol-4-Yl]-1h-1,2,3,4-Tetrazole NFE2 like bZIP transcription factor 2 Rattus norvegicus
2 To detect GOH effect against liver IRI through the activation of the Nrf2/HO-1 antioxidant pathway, five groups of rats were randomized to normal, sham, IR, GOH, and GOH/IR. 5-[2-Cyclopropyl-5-(1h-Pyrrol-1-Yl)-1,3-Oxazol-4-Yl]-1h-1,2,3,4-Tetrazole heme oxygenase 1 Rattus norvegicus
3 GOH induces activation of Nrf2 along with the upregulation of HO-1 expression. 5-[2-Cyclopropyl-5-(1h-Pyrrol-1-Yl)-1,3-Oxazol-4-Yl]-1h-1,2,3,4-Tetrazole NFE2 like bZIP transcription factor 2 Rattus norvegicus
4 GOH induces activation of Nrf2 along with the upregulation of HO-1 expression. 5-[2-Cyclopropyl-5-(1h-Pyrrol-1-Yl)-1,3-Oxazol-4-Yl]-1h-1,2,3,4-Tetrazole heme oxygenase 1 Rattus norvegicus
5 Regarding the anti-inflammatory effect of GOH, it suppresses the levels of TNF-alpha, iNOS, and COX-2. 5-[2-Cyclopropyl-5-(1h-Pyrrol-1-Yl)-1,3-Oxazol-4-Yl]-1h-1,2,3,4-Tetrazole tumor necrosis factor Rattus norvegicus
6 Regarding the anti-inflammatory effect of GOH, it suppresses the levels of TNF-alpha, iNOS, and COX-2. 5-[2-Cyclopropyl-5-(1h-Pyrrol-1-Yl)-1,3-Oxazol-4-Yl]-1h-1,2,3,4-Tetrazole nitric oxide synthase 2 Rattus norvegicus
7 Regarding the anti-inflammatory effect of GOH, it suppresses the levels of TNF-alpha, iNOS, and COX-2. 5-[2-Cyclopropyl-5-(1h-Pyrrol-1-Yl)-1,3-Oxazol-4-Yl]-1h-1,2,3,4-Tetrazole cytochrome c oxidase II, mitochondrial Rattus norvegicus