Protein Name peroxisome proliferator activated receptor alpha
Organism Homo sapiens
Gene ID 5465
Gene Symbol


UniProt Q07869 (PPARA_HUMAN), F1D8S4 (F1D8S4_HUMAN)
Relationships Total Number of functionally related compound(s) : 1347
Total Number of Articles : 2818

peroxisome proliferator activated receptor alpha

Gene Summary

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

  • peroxisome proliferator-activated receptor alpha
  • nuclear receptor subfamily 1 group C member 1
  • peroxisome proliferative activated receptor, alpha
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