Title : Significance of p27 as potential biomarker for intracellular oxidative status.

Pub. Date : 2010 Oct

PMID : 21103079






10 Functional Relationships(s)
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Protein Name
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1 Our previous proteomic study demonstrated that oxidative stress and antioxidant delphinidin regulated the cellular level of p27(kip1) (referred to as p27) as well as some heat shock proteins in human colon cancer HT 29 cells. delphinidin interferon alpha inducible protein 27 Homo sapiens
2 Our previous proteomic study demonstrated that oxidative stress and antioxidant delphinidin regulated the cellular level of p27(kip1) (referred to as p27) as well as some heat shock proteins in human colon cancer HT 29 cells. delphinidin cyclin dependent kinase inhibitor 1B Homo sapiens
3 Our previous proteomic study demonstrated that oxidative stress and antioxidant delphinidin regulated the cellular level of p27(kip1) (referred to as p27) as well as some heat shock proteins in human colon cancer HT 29 cells. delphinidin interferon alpha inducible protein 27 Homo sapiens
4 While the level of p27 was responsive to hydrogen peroxide and delphinidin, it remained unchanged in BPRc1, suggesting that the regulation of p27 requires functional HIF-1beta. delphinidin interferon alpha inducible protein 27 Homo sapiens
5 We also found that hydrogen peroxide and delphinidin affected PI3K/Akt/mTOR signaling pathway which is one of upstream regulators of HIFs. delphinidin AKT serine/threonine kinase 1 Homo sapiens
6 We also found that hydrogen peroxide and delphinidin affected PI3K/Akt/mTOR signaling pathway which is one of upstream regulators of HIFs. delphinidin mechanistic target of rapamycin kinase Homo sapiens
7 In conclusion, hydrogen peroxide and antioxidant delphinidin seem to regulate intracellular level of p27 through regulating HIF-1 level which is, in turn, governed by its upstream regulators comprising of PI3K/Akt/mTOR signaling pathway. delphinidin interferon alpha inducible protein 27 Homo sapiens
8 In conclusion, hydrogen peroxide and antioxidant delphinidin seem to regulate intracellular level of p27 through regulating HIF-1 level which is, in turn, governed by its upstream regulators comprising of PI3K/Akt/mTOR signaling pathway. delphinidin hypoxia inducible factor 1 subunit alpha Homo sapiens
9 In conclusion, hydrogen peroxide and antioxidant delphinidin seem to regulate intracellular level of p27 through regulating HIF-1 level which is, in turn, governed by its upstream regulators comprising of PI3K/Akt/mTOR signaling pathway. delphinidin AKT serine/threonine kinase 1 Homo sapiens
10 In conclusion, hydrogen peroxide and antioxidant delphinidin seem to regulate intracellular level of p27 through regulating HIF-1 level which is, in turn, governed by its upstream regulators comprising of PI3K/Akt/mTOR signaling pathway. delphinidin mechanistic target of rapamycin kinase Homo sapiens