Pub. Date : 2007 Feb 15
PMID : 17113042
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Myricetin induces human osteoblast differentiation through bone morphogenetic protein-2/p38 mitogen-activated protein kinase pathway. | myricetin | bone morphogenetic protein 2 | Homo sapiens |
| 2 | Myricetin induces human osteoblast differentiation through bone morphogenetic protein-2/p38 mitogen-activated protein kinase pathway. | myricetin | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | By means of alkaline phosphatase (ALP) activity, osteocalcin, and type I collagen enzyme-linked immunosorbent assay (ELISA), we have shown that myricetin exhibits a significant induction of differentiation in MG-63 and hFOB human osteoblasts. | myricetin | alkaline phosphatase, placental | Homo sapiens |
| 4 | By means of alkaline phosphatase (ALP) activity, osteocalcin, and type I collagen enzyme-linked immunosorbent assay (ELISA), we have shown that myricetin exhibits a significant induction of differentiation in MG-63 and hFOB human osteoblasts. | myricetin | alkaline phosphatase, placental | Homo sapiens |
| 5 | By means of alkaline phosphatase (ALP) activity, osteocalcin, and type I collagen enzyme-linked immunosorbent assay (ELISA), we have shown that myricetin exhibits a significant induction of differentiation in MG-63 and hFOB human osteoblasts. | myricetin | bone gamma-carboxyglutamate protein | Homo sapiens |
| 6 | Induction of differentiation by myricetin is associated with increased bone morphogenetic protein-2 (BMP-2) production. | myricetin | bone morphogenetic protein 2 | Homo sapiens |
| 7 | Induction of differentiation by myricetin is associated with increased bone morphogenetic protein-2 (BMP-2) production. | myricetin | bone morphogenetic protein 2 | Homo sapiens |
| 8 | Induction of differentiation by myricetin is associated with increased activation of SMAD1/5/8 and p38 mitogen-activated protein kinases. | myricetin | SMAD family member 1 | Homo sapiens |
| 9 | Induction of differentiation by myricetin is associated with increased activation of SMAD1/5/8 and p38 mitogen-activated protein kinases. | myricetin | mitogen-activated protein kinase 14 | Homo sapiens |
| 10 | Cotreatment of p38 inhibitor SB203580 inhibited myricetin-mediated ALP upregulation and osteocalcin production. | myricetin | mitogen-activated protein kinase 14 | Homo sapiens |
| 11 | Cotreatment of p38 inhibitor SB203580 inhibited myricetin-mediated ALP upregulation and osteocalcin production. | myricetin | alkaline phosphatase, placental | Homo sapiens |
| 12 | In conclusion, myricetin increased BMP-2 synthesis, and subsequently activated SMAD1/5/8 and p38 MAPK, and this effect may contribute to its action on the induction of osteoblast maturation and differentiation, followed by an increase of bone mass. | myricetin | bone morphogenetic protein 2 | Homo sapiens |
| 13 | In conclusion, myricetin increased BMP-2 synthesis, and subsequently activated SMAD1/5/8 and p38 MAPK, and this effect may contribute to its action on the induction of osteoblast maturation and differentiation, followed by an increase of bone mass. | myricetin | SMAD family member 1 | Homo sapiens |
| 14 | In conclusion, myricetin increased BMP-2 synthesis, and subsequently activated SMAD1/5/8 and p38 MAPK, and this effect may contribute to its action on the induction of osteoblast maturation and differentiation, followed by an increase of bone mass. | myricetin | mitogen-activated protein kinase 14 | Homo sapiens |