4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline

epidermal growth factor receptor ; Homo sapiens







121 Article(s)
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1 32236267 Novel anilino quinazoline-based EGFR tyrosine kinase inhibitors for treatment of non-small cell lung cancer. 2021 Jan 21 1
2 34885111 Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer. 2021 Nov 29 1
3 31936670 The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients. 2020 Jan 9 3
4 30290164 ERK1/2-mediated EGFR-signaling is required for TGFβ-induced lens epithelial-mesenchymal transition. 2019 Jan 1
5 29518481 Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo. 2018 Jun 28 3
6 29751044 Transcriptional repressor Kaiso promotes epithelial to mesenchymal transition and metastasis in prostate cancer through direct regulation of miR-200c. 2018 Sep 1 2
7 26334931 Predictive efficacy of (11)C-PD153035 PET imaging for EGFR-tyrosine kinase inhibitor sensitivity in non-small cell lung cancer patients. 2016 Feb 15 4
8 26986216 Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia. 2016 May 1
9 27220321 SH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/P-glycoprotein via EGFR/ERK/AP-1 pathway. 2016 Sep 1
10 23765435 Pb2+ induces gastrin gene expression by extracellular signal-regulated kinases 1/2 and transcription factor activator protein 1 in human gastric carcinoma cells. 2015 Feb 2
11 24639330 Function of DNA methyltransferase 3a in lead (Pb(2+) )-Induced Cyclooxygenase-2 gene. 2015 Sep 1
12 25482018 Ovarian cancer ascites enhance the migration of patient-derived peritoneal mesothelial cells via cMet pathway through HGF-dependent and -independent mechanisms. 2015 Jul 15 3
13 24335566 A pilot study on EGFR-targeted molecular imaging of PET/CT With 11C-PD153035 in human gliomas. 2014 Jan 2
14 25124631 Aquaporin 8 involvement in human cervical cancer SiHa migration via the EGFR-Erk1/2 pathway. 2014 2
15 25329617 Squamosamide derivative FLZ protects retinal pigment epithelium cells from oxidative stress through activation of epidermal growth factor receptor (EGFR)-AKT signaling. 2014 Oct 17 2
16 25550802 Aquaporin-8 mediates human esophageal cancer Eca-109 cell migration via the EGFR-Erk1/2 pathway. 2014 1
17 24354805 Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors. 2013 Dec 19 1
18 21964676 Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance. 2012 Jan 1
19 22517768 Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells. 2012 Jul 1
20 22613406 Therapeutic and preventive effects of an epidermal growth factor receptor inhibitor on oral squamous cell carcinoma. 2012 3
21 22712848 Pollutant particles induce arginase II in human bronchial epithelial cells. 2012 1
22 22735833 Epidermal growth factor enhances MPC-83 pancreatic cancer cell migration through the upregulation of aquaporin 3. 2012 Sep 2
23 22797910 The tyrosine phosphatase SHP-1 negatively regulates cytotrophoblast proliferation in first-trimester human placenta by modulating EGFR activation. 2012 Dec 1
24 22974583 Nuclear Kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells. 2012 Nov 2
25 21130075 Determining the binding mode and binding affinity constant of tyrosine kinase inhibitor PD153035 to DNA using optical tweezers. 2011 Jan 7 1
26 21435385 Divalent lead cations induce cyclooxygenase-2 gene expression by epidermal growth factor receptor/nuclear factor-kappa B signaling in A431carcinoma cells. 2011 Jun 10 1
27 21472131 Trefoil factors: tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma. 2011 Mar 28 2
28 21820892 Label-free electrochemical measurement of protein tyrosine kinase activity and inhibition based on electro-catalyzed tyrosine signaling. 2011 Oct 15 1
29 21903741 Molecular imaging with 11C-PD153035 PET/CT predicts survival in non-small cell lung cancer treated with EGFR-TKI: a pilot study. 2011 Oct 3
30 22866118 Activation of acetyl-coenzyme A carboxylase is involved in Taxol-induced ovarian cancer cell death. 2011 May 1
31 20538380 Synthesis and initial tumor affinity testing of iodine-123 labelled EGFR-affine agents as potential imaging probes for hormone-refractory prostate cancer. 2010 Sep 3
32 20882990 Identification of the amyloid β-protein precursor and cystatin C as novel epidermal growth factor receptor regulated secretory proteins in nasopharyngeal carcinoma by proteomics. 2010 Dec 3 1
33 19133285 Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling. 2009 Mar 1 2
34 19376214 Fluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells. 2009 Aug 10 2
35 19804359 EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells. 2009 Dec 1
36 17882547 Amphiregulin-EGFR signaling regulates PTHrP gene expression in breast cancer cells. 2008 Aug 2
37 18346929 Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide. 2008 1
38 18400375 Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs. 2008 Aug 8 4
39 18636178 Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes. 2008 Aug 1
40 18802922 Specific signaling cascades involved in cell spreading during healing of micro-wounded gastric epithelial monolayers. 2008 Dec 1 1
41 18986098 Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor. 2008 1
42 19069650 [Involvement of EGF receptor and PI3K in ICAM-1 expression in human airway epithelial cells exposed to zinc sulfate]. 2008 Sep 2
43 16837130 Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma. 2007 Apr 8 2
44 16956907 EGFR and Src are involved in indole-3-carbinol-induced death and cell cycle arrest of human breast cancer cells. 2007 Feb 1
45 17028263 Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells. 2007 Feb 2
46 17286282 Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways. 2007 Jun 5
47 17293597 Protein C is an autocrine growth factor for human skin keratinocytes. 2007 May 4 2
48 17533397 Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice. 2007 Jul 16 1
49 17608728 The DNA-binding epidermal growth factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic acid receptor-beta tumor-suppressor gene in breast cancer cells. 2007 Nov 6
50 17624262 Further characterization of the epidermal growth factor receptor ligand 11C-PD153035. 2007 Jun 5 3