Title : Identification of the amyloid β-protein precursor and cystatin C as novel epidermal growth factor receptor regulated secretory proteins in nasopharyngeal carcinoma by proteomics.

Pub. Date : 2010 Dec 3

PMID : 20882990






1 Functional Relationships(s)
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1 We further showed that the secretory changes of APP and cystatin C in CNE-2 after TGF-alpha stimulation could be abrogated by pretreatment of EGFR tyrosine kinase inhibitor PD153035 and PI3 kinase inhibitor Wortmannin, validating that APP and cystatin C are EGFR-regulated secreted proteins in NPC cells. 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline epidermal growth factor receptor Homo sapiens