vandetanib

epidermal growth factor receptor ; Homo sapiens







155 Article(s)
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51 21095630 Epidermal growth factor receptor expression modulates antitumor efficacy of vandetanib or cediranib combined with radiotherapy in human glioblastoma xenografts. 2012 Jan 1 3
52 22025146 Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. 2012 Jan 10 1
53 22075979 Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial growth factor receptor 2 protein without a prominent role for miR-296. 2012 Feb 1
54 22158569 Vandetanib for the treatment of thyroid cancer. 2012 Jan 2
55 22184381 Double-blind, randomized trial of docetaxel plus vandetanib versus docetaxel plus placebo in platinum-pretreated metastatic urothelial cancer. 2012 Feb 10 1
56 22206795 Pharmacokinetics of vandetanib: three phase I studies in healthy subjects. 2012 Jan 1
57 22245891 Vandetanib in patients with inoperable hepatocellular carcinoma: a phase II, randomized, double-blind, placebo-controlled study. 2012 May 1
58 22258476 Combining the multitargeted tyrosine kinase inhibitor vandetanib with the antiestrogen fulvestrant enhances its antitumor effect in non-small cell lung cancer. 2012 Mar 5
59 22307735 Antitumor effect of vandetanib through EGFR inhibition in head and neck squamous cell carcinoma. 2012 Sep 3
60 22336242 [Vandetanib treatment in refractory advanced lung adenocarcinoma patients: five cases and review of literature]. 2012 Feb 1
61 22343387 Recent advances in the molecular pathogenesis and targeted therapies of medullary thyroid carcinoma. 2012 May 2
62 22370318 Vandetanib Versus placebo in patients with advanced non-small-cell lung cancer after prior therapy with an epidermal growth factor receptor tyrosine kinase inhibitor: a randomized, double-blind phase III trial (ZEPHYR). 2012 Apr 1 4
63 22378813 Risk of rash in cancer patients treated with vandetanib: systematic review and meta-analysis. 2012 Apr 1
64 22429581 [Vandetanib for advanced non-small cell lung cancer: a meta-analysis]. 2012 Mar 2
65 22484209 Inhibition of P-glycoprotein functionality by vandetanib may reverse cancer cell resistance to doxorubicin. 2012 Aug 15 1
66 22500115 Role of vandetanib in the management of medullary thyroid cancer. 2012 1
67 22505191 Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms. 2012 Jul 2
68 22548830 Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: implications for the emergence and reversal of cancer drug resistance. 2012 Aug 1 1
69 22646768 Inhibition of non-small-cell lung cancer growth by combined fulvestrant and vandetanib. 2012 May 1
70 22667325 Vandetanib for the treatment of lung cancer. 2012 Aug 1
71 22701615 Phase I study of cetuximab, irinotecan, and vandetanib (ZD6474) as therapy for patients with previously treated metastastic colorectal cancer. 2012 1
72 22715896 Vandetanib: in medullary thyroid cancer. 2012 Jul 9 2
73 22898678 Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial. 2012 Sep 1
74 23099652 A phase I/II trial of vandetanib for patients with recurrent malignant glioma. 2012 Dec 1
75 20665703 ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells. 2011 Feb 2
76 20943719 The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells. 2011 Feb 6
77 21247406 Emerging therapies in the treatment of locally advanced squamous cell cancers of head and neck. 2011 May 1
78 21282537 Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: a randomized, double-blind phase III trial. 2011 Mar 10 1
79 21282542 Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer. 2011 Mar 10 1
80 21350000 Vandetanib restores head and neck squamous cell carcinoma cells' sensitivity to cisplatin and radiation in vivo and in vitro. 2011 Apr 1 2
81 21537841 Vandetanib inhibits both VEGFR-2 and EGFR signalling at clinically relevant drug levels in preclinical models of human cancer. 2011 Jul 7
82 21600385 Pharmacokinetics and tolerability of vandetanib in Chinese patients with solid, malignant tumors: an open-label, phase I, rising multiple-dose study. 2011 Mar 2
83 21723791 Integration of EGFR inhibitors and conventional chemotherapy in the treatment of non-small-cell lung cancer. 2011 Nov 1
84 21770481 Vandetanib: first global approval. 2011 Jul 9 4
85 21819274 Vandetanib for the treatment of non-small-cell lung cancer. 2011 Oct 1
86 21836817 Vandetanib (ZD6474) in the Treatment of Medullary Thyroid Cancer. 2011 4
87 21921646 Phase I dose-finding study of vandetanib in combination with gemcitabine in locally advanced unresectable or metastatic pancreatic adenocarcinoma. 2011 1
88 21970874 Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin. 2011 Nov 8 3
89 22346266 Photosensitivity reactions to vandetanib: redevelopment after sequential treatment with docetaxel. 2011 Dec 2
90 22393954 Efficacy and safety of vandetanib, a dual VEGFR and EGFR inhibitor, in advanced non-small-cell lung cancer: a systematic review and meta-analysis. 2011 2
91 23148184 Thyroid cancer: pathogenesis and targeted therapy. 2011 Oct 1
92 20065189 Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. 2010 Feb 10 1
93 20068097 Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2. 2010 Jan 15 1
94 20137866 Phase I study of vandetanib with radiotherapy and temozolomide for newly diagnosed glioblastoma. 2010 Sep 1 1
95 20139705 ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells. 2010 Apr 15 3
96 20225331 A novel therapeutic combination for neuroblastoma: the vascular endothelial growth factor receptor/epidermal growth factor receptor/rearranged during transfection inhibitor vandetanib with 13-cis-retinoic acid. 2010 May 15 2
97 20371720 ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain. 2010 Apr 5
98 20570559 Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. 2010 Jul 2
99 20661087 A phase I study of Vandetanib in combination with vinorelbine/cisplatin or gemcitabine/cisplatin as first-line treatment for advanced non-small cell lung cancer. 2010 Aug 1
100 20859451 Current status of vandetanib (ZD6474) in the treatment of non-small cell lung cancer. 2010 Sep 13 4