Pub. Date : 2004 Feb 1
PMID : 14751502
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. | Lapatinib | epidermal growth factor receptor | Homo sapiens | ||
2 | RESULTS: GW572016 inhibited constitutive and/or ligand-induced EGFR or HER2 tyrosine phosphorylation of all five cell lines, which correlated with the antiproliferative response in all but one cell line. | Lapatinib | epidermal growth factor receptor | Homo sapiens | ||
3 | GW572016 radiosensitized EGFR-overexpressing cell lines, but HER2-overexpressing cells were unable to form colonies after brief exposure to GW572016 even in the absence of radiation, and thus could not be evaluated for radiosensitization. | Lapatinib | epidermal growth factor receptor | Homo sapiens | ||
4 | CONCLUSION: GW572016 potently inhibits receptor phosphorylation in either EGFR- or HER2-overexpressing cell lines and has both antiproliferative and radiosensitizing effects. | Lapatinib | epidermal growth factor receptor | Homo sapiens |