Title : Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance.

Pub. Date : 2004 Feb 1

PMID : 14751502






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. Lapatinib epidermal growth factor receptor Homo sapiens
2 RESULTS: GW572016 inhibited constitutive and/or ligand-induced EGFR or HER2 tyrosine phosphorylation of all five cell lines, which correlated with the antiproliferative response in all but one cell line. Lapatinib epidermal growth factor receptor Homo sapiens
3 GW572016 radiosensitized EGFR-overexpressing cell lines, but HER2-overexpressing cells were unable to form colonies after brief exposure to GW572016 even in the absence of radiation, and thus could not be evaluated for radiosensitization. Lapatinib epidermal growth factor receptor Homo sapiens
4 CONCLUSION: GW572016 potently inhibits receptor phosphorylation in either EGFR- or HER2-overexpressing cell lines and has both antiproliferative and radiosensitizing effects. Lapatinib epidermal growth factor receptor Homo sapiens