Pub. Date : 2015 Dec
PMID : 26142736
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As a target of 5-FU, thymidylate synthase (TS) expression level might be influenced by irinotecan. | Irinotecan | thymidylate synthetase | Homo sapiens |
| 2 | As a target of 5-FU, thymidylate synthase (TS) expression level might be influenced by irinotecan. | Irinotecan | thymidylate synthetase | Homo sapiens |
| 3 | Understanding whether this influence of TS is related with MMR status is helpful to the further exploration of the mechanism of irinotecan sensitivity in metastatic colon cancer with different MMR status. | Irinotecan | thymidylate synthetase | Homo sapiens |
| 4 | Regulation of TS by irinotecan was evaluated by western blotting and quantitative real-time PCR assay. | Irinotecan | thymidylate synthetase | Homo sapiens |
| 5 | TS expression level was reduced more in dMMR cells after irinotecan treatment (p < 0.05). | Irinotecan | thymidylate synthetase | Homo sapiens |