celastrol

AKT serine/threonine kinase 1 ; Homo sapiens







28 Article(s)
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1 32116702 Celastrol Suppresses Glioma Vasculogenic Mimicry Formation and Angiogenesis by Blocking the PI3K/Akt/mTOR Signaling Pathway. 2020 3
2 30389635 Celastrol strongly inhibits proliferation, migration and cancer stem cell properties through suppression of Pin1 in ovarian cancer cells. 2019 Jan 5 1
3 30709873 Correction: Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway. 2019 Feb 1 1
4 30913029 Tripterine inhibits proliferation, migration and invasion of breast cancer MDA-MB-231 cells by up-regulating microRNA-15a. 2019 Apr 22 2
5 30989726 Celastrol inhibits growth and metastasis of human gastric cancer cell MKN45 by down-regulating microRNA-21. 2019 Jun 2
6 31053160 Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells. 2019 May 3 3
7 31266528 Correction to: Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells. 2019 Jul 2 1
8 29553945 Celastrol inhibits colorectal cancer cell proliferation and migration through suppression of MMP3 and MMP7 by the PI3K/AKT signaling pathway. 2018 Jul 4
9 27891586 Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca2+ -CaMKII-Dependent Akt/mTOR Pathway. 2017 Aug 9
10 28459364 Cytotoxic effect of celastrol alone or in combination with paclitaxel on anaplastic thyroid carcinoma cells. 2017 May 1
11 27144550 Celastrol Induces Cell Apoptosis and Inhibits the Expression of the AML1-ETO/C-KIT Oncoprotein in t(8;21) Leukemia. 2016 Apr 30 1
12 27671821 Celastrol and Its Role in Controlling Chronic Diseases. 2016 1
13 27840916 Effects of celastrol on enhancing apoptosis of ovarian cancer cells via the downregulation of microRNA‑21 and the suppression of the PI3K/Akt‑NF‑κB signaling pathway in an in vitro model of ovarian carcinoma. 2016 Dec 2
14 27900015 Celastrol negatively regulates cell invasion and migration ability of human osteosarcoma via downregulation of the PI3K/Akt/NF-κB signaling pathway in vitro. 2016 Nov 3
15 25818165 Anticancer effect of celastrol on human triple negative breast cancer: possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways. 2015 Jun 7
16 25961164 Celastrol Protects against Antimycin A-Induced Insulin Resistance in Human Skeletal Muscle Cells. 2015 May 7 1
17 26447544 Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine. 2015 Oct 20 1
18 24111524 Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network. 2014 Jan 6
19 24434352 Celastrol induces apoptosis of gastric cancer cells by miR-21 inhibiting PI3K/Akt-NF-κB signaling pathway. 2014 6
20 24667175 Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy. 2014 Dec 1
21 25383959 Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis. 2014 5
22 23810294 Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways. 2013 Sep 1 2
23 23988648 miR-224 is critical for celastrol-induced inhibition of migration and invasion of hepatocellular carcinoma cells. 2013 2
24 22683631 Celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells. 2012 Jul 6 2
25 21168266 Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer. 2011 Apr 1 1
26 21466843 Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways. 2011 Aug 1
27 21786165 Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways. 2011 Oct 3
28 20160026 Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. 2010 Mar 1 4