Pub. Date : 2020
PMID : 32116702
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol Suppresses Glioma Vasculogenic Mimicry Formation and Angiogenesis by Blocking the PI3K/Akt/mTOR Signaling Pathway. | celastrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In vitro, we further demonstrated that celastrol inhibited the growth, migration, and invasion of U87 and U251 cells, disrupted VM formation, and blocked the activity of PI3K, Akt, and mTOR. | celastrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Collectively, our data suggest that celastrol inhibits VM formation and angiogenesis likely by regulating the PI3K/Akt/mTOR signaling pathway. | celastrol | AKT serine/threonine kinase 1 | Homo sapiens |