Pub. Date : 2018 Jul
PMID : 29553945
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol inhibits colorectal cancer cell proliferation and migration through suppression of MMP3 and MMP7 by the PI3K/AKT signaling pathway. | celastrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Celastrol treatment also decreased the PI3K/AKT pathway components, and MMP3 and MMP7 expression levels. | celastrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In addition, knockdown of AKT, not mTOR, inhibited MMP3 and MMP7 expression levels and AKT silencing promoted the celastrol-induced effects on CRC cell proliferation and migration. | celastrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Taken together, these findings indicated that the celastrol-induced antitumor effects were mediated through MMP3 and MMP7 by the PI3K/AKT signaling pathway. | celastrol | AKT serine/threonine kinase 1 | Homo sapiens |