Pub. Date : 2010 Mar 1
PMID : 20160026
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. | celastrol | AKT serine/threonine kinase 1 | Homo sapiens | ||
| 2 | Celastrol suppressed the VEGF-induced activation of AKT, mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase (P70S6K). | celastrol | AKT serine/threonine kinase 1 | Homo sapiens | ||
| 3 | Additionally, we found that Celastrol inhibited the proliferation of prostate cancer cells and induced apoptosis, and these effects correlated with the extent of inhibition of AKT/mTOR/P70S6K signaling. | celastrol | AKT serine/threonine kinase 1 | Homo sapiens | ||
| 4 | Taken together, our results suggest that Celastrol targets the AKT/mTOR/P70S6K pathway, which leads to suppression of tumor growth and angiogenesis. | celastrol | AKT serine/threonine kinase 1 | Homo sapiens | ||