Wortmannin

AKT serine/threonine kinase 1 ; Homo sapiens







540 Article(s)
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51 28337019 Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. 2017 Mar 23 1
52 28381122 Argon Exposure Induces Postconditioning in Myocardial Ischemia-Reperfusion. 2017 Nov 1
53 28395342 Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy. 2017 Jan 1 1
54 28413728 Mechanism of endothelial nitric oxide synthase phosphorylation and activation by tentacle extract from the jellyfish Cyanea capillata. 2017 1
55 28440394 G-protein-coupled receptor 30 mediates the effects of estrogen on endothelial cell tube formation in vitro. 2017 Jun 1
56 28474373 Angiopoietin-1 and angiopoietin-2 protect porcine iliac endothelial cells from human antibody-mediated complement-dependent cytotoxicity through phosphatidylinositide 3-kinase/AKT pathway activation. 2017 Jul 1
57 28559962 Icariside II promotes the osteogenic differentiation of canine bone marrow mesenchymal stem cells via the PI3K/AKT/mTOR/S6K1 signaling pathways. 2017 1
58 28645612 IL-1β induced methylation of the estrogen receptor ERα gene correlates with EMT and chemoresistance in breast cancer cells. 2017 Aug 26 1
59 28656239 Erythropoietin ameliorates PA-induced insulin resistance through the IRS/AKT/FOXO1 and GSK-3β signaling pathway, and inhibits the inflammatory response in HepG2 cells. 2017 Aug 1
60 28974422 Thyroid hormone regulates fibronectin expression through the activation of the hypoxia inducible factor 1. 2017 Nov 25 1
61 29050941 Mahanine enhances the glucose-lowering mechanisms in skeletal muscle and adipocyte cells. 2017 Dec 9 2
62 26084532 Early Growth Response Protein-1 Expression by Insulin-Like Growth Factor-1 Requires ROS-Dependent Activation of ERK1/2 and PKB Pathways in Vascular Smooth Muscle Cells. 2016 Jan 1
63 26709648 GMP-grade platelet lysate enhances proliferation and migration of tenon fibroblasts. 2016 Jan 1 1
64 26855332 PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs. 2016 Mar 1
65 26910892 CD133 promotes gallbladder carcinoma cell migration through activating Akt phosphorylation. 2016 Apr 5 1
66 26921757 Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition. 2016 Apr 5 1
67 26923291 SIRT1 mediates Sphk1/S1P-induced proliferation and migration of endothelial cells. 2016 May 1
68 26925782 Reversal of cisplatin resistance by inhibiting PI3K/Akt signal pathway in human lung cancer cells. 2016 1
69 26984633 Timosaponin A-III reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway. 2016 May 2
70 26994617 The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells. 2016 Aug 1
71 27026591 Hydrogen sulfide prevents Abeta-induced neuronal apoptosis by attenuating mitochondrial translocation of PTEN. 2016 Jun 14 1
72 27030608 Exendin-4 protects HUVECs from t-BHP-induced apoptosis via PI3K/Akt-Bcl-2-caspase-3 signaling. 2016 Aug 1
73 27059084 Low Oxygen Modulates Multiple Signaling Pathways, Increasing Self-Renewal, While Decreasing Differentiation, Senescence, and Apoptosis in Stromal MIAMI Cells. 2016 Jun 1 1
74 27107935 Estrogen receptor beta (ERβ) mediates expression of β-catenin and proliferation in prostate cancer cell line PC-3. 2016 Jul 15 1
75 27107990 COMP-Ang1 enhances DNA synthesis and cell cycle progression in human periodontal ligament cells via Tie2-mediated phosphorylation of PI3K/Akt and MAPKs. 2016 May 1
76 27126362 Activation of AKT negatively regulates the pro-apoptotic function of death-associated protein kinase 3 (DAPK3) in prostate cancer. 2016 Jul 28 1
77 27138223 PI3K/AKT Signaling Pathway Is Essential for Survival of Induced Pluripotent Stem Cells. 2016 3
78 27155335 Loss of Akt increases soluble endoglin release from endothelial cells but not placenta. 2016 Apr 1
79 27357941 Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells. 2016 Jun 30 2
80 27456341 Hyperthermia induced HIF-1a expression of lung cancer through AKT and ERK signaling pathways. 2016 Jul 26 1
81 27591897 The Vascular Endothelial Growth Factor-A phosphorylates Murine Double Minute-2 on its Serine 166 via the Extracellular Signal-Regulated Kinase 1/2 and p90 Ribosomal S6 Kinase in primary human endothelial cells. 2016 Sep 30 1
82 27777878 Role of Akt signaling in resistance to DNA-targeted therapy. 2016 Oct 10 1
83 28064317 [B7-H4-mediated immunoresistance is supressed by PI3K/Akt/mTOR pathway inhibitors]. 2016 Nov-Dec 1
84 24706111 microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imatinib through PI3K/AKT pathway. 2015 May 1
85 25002221 Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells. 2015 Aug 1
86 25424831 AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation. 2015 Apr 1
87 25446112 DPP IV inhibitor suppresses STZ-induced islets injury dependent on activation of the IGFR/Akt/mTOR signaling pathways by GLP-1 in monkeys. 2015 Jan 2 1
88 25454806 Unfractionated heparin attenuates LPS-induced IL-8 secretion via PI3K/Akt/NF-κB signaling pathway in human endothelial cells. 2015 Mar 1
89 25545050 HSPA12B inhibits lipopolysaccharide-induced inflammatory response in human umbilical vein endothelial cells. 2015 Mar 1
90 25568334 Inactivation of GSK3β and activation of NF-κB pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma. 2015 Mar 1 1
91 25635866 A critical dose of doxorubicin is required to alter the gene expression profiles in MCF-7 cells acquiring multidrug resistance. 2015 1
92 25636880 Pharmacogenomic and molecular docking studies on the cytotoxicity of the natural steroid wortmannin against multidrug-resistant tumor cells. 2015 Jan 15 1
93 25658447 PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures. 2015 1
94 25663935 FOXP1 regulation via the PI3K/Akt/p70S6K signaling pathway in breast cancer cells. 2015 Mar 2
95 25797048 Phosphatidylinositol-3,4,5-trisphosphate stimulates Ca(2+) elevation and Akt phosphorylation to constitute a major mechanism of thromboxane A2 formation in human platelets. 2015 Jul 1
96 25858425 Akt and mitogen-activated protein kinase enhance C-type lectin-like receptor 2-mediated platelet activation by inhibition of glycogen synthase kinase 3α/β. 2015 Jun 1
97 25925728 Ghrelin promotes renal cell carcinoma metastasis via Snail activation and is associated with poor prognosis. 2015 Sep 1
98 26251974 Cyclic mechanical stretch promotes energy metabolism in osteoblast-like cells through an mTOR signaling-associated mechanism. 2015 Oct 2
99 26260024 The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunction. 2015 Aug 11 1
100 26339054 Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization. 2015 Nov 1