Fingolimod Hydrochloride

protein phosphatase 2 phosphatase activator ; Homo sapiens







19 Article(s)
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1 34382511 SK1 Inhibitor RB005 Induces Apoptosis in Colorectal Cancer Cells through SK1 Inhibition Dependent and Independent Pathway. 2022 1
2 33932092 SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A-c-Myc axis. 2021 Nov 1
3 31593801 A novel FTY720 analogue targets SET-PP2A interaction and inhibits growth of acute myeloid leukemia cells without inducing cardiac toxicity. 2020 Jan 1 2
4 33069748 Restoration of PP2A levels in inflamed microglial cells: Important for neuroprotective M2 microglial viability. 2020 Dec 15 1
5 30917007 The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction. 2019 Jun 2
6 29986744 Protein phosphatase 2A activation mechanism contributes to JS-K induced caspase-dependent apoptosis in human hepatocellular carcinoma cells. 2018 Jul 9 1
7 28813646 Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells. 2017 Nov 15 1
8 26967515 A systematic evaluation of the safety and toxicity of fingolimod for its potential use in the treatment of acute myeloid leukaemia. 2016 Jul 2
9 27556014 The broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance. 2016 Dec 1
10 25637283 Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer. 2015 Apr 1
11 25699237 Therapeutic Re-Activation of Protein Phosphatase 2A in Acute Myeloid Leukemia. 2015 1
12 26023836 Activation of the Tumor Suppressor PP2A Emerges as a Potential Therapeutic Strategy for Treating Prostate Cancer. 2015 May 27 4
13 25207757 Modulation of IL-33/ST2-TIR and TLR signalling pathway by fingolimod and analogues in immune cells. 2014 Dec 3
14 22109829 Reactivating PP2A by FTY720 as a novel therapy for AML with C-KIT tyrosine kinase domain mutation. 2012 Apr 3
15 21233840 PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect. 2011 Apr 2
16 18213449 Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias. 2008 Jun 1
17 17717597 FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. 2007 Sep 1
18 12711631 A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells. 2003 Apr 2
19 11429058 Coordinate involvement of cell cycle arrest and apoptosis strengthen the effect of FTY720. 2001 Jun 1