Pub. Date : 2015 May 27
PMID : 26023836
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We treated PC-3 and LNCaP cell lines with the PP2A activators forskolin and FTY720 alone or combined with the PP2A inhibitor okadaic acid. | Fingolimod Hydrochloride | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 2 | Interestingly, both forskolin and FTY720 dephosphorylated and activated PP2A, impairing proliferation and prostasphere formation and inducing changes in AKT and ERK phosphorylation. | Fingolimod Hydrochloride | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 3 | Treatment with okadaic acid impaired PP2A activation thus demonstrating the antitumoral PP2A-dependent mechanism of action of both forskolin and FTY720. | Fingolimod Hydrochloride | protein phosphatase 2 phosphatase activator | Homo sapiens |
| 4 | Treatment with okadaic acid impaired PP2A activation thus demonstrating the antitumoral PP2A-dependent mechanism of action of both forskolin and FTY720. | Fingolimod Hydrochloride | protein phosphatase 2 phosphatase activator | Homo sapiens |