PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17717597-3 2007 We assessed the therapeutic potential of the PP2A activator FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride), an immunomodulator in Phase III trials for patients with multiple sclerosis or undergoing organ transplantation, in CML-BC and Ph1 ALL patient cells and in in vitro and in vivo models of these BCR/ABL+ leukemias. Fingolimod Hydrochloride 68-132 protein phosphatase 2 phosphatase activator Homo sapiens 45-49 18213449-5 2008 Remarkably, drugs such as forskolin, 1,9-dideoxy-forskolin and FTY720 which lead to PP2A activation effectively antagonize leukemogenesis in both in vitro and in vivo models of these cancers. Fingolimod Hydrochloride 63-69 protein phosphatase 2 phosphatase activator Homo sapiens 84-88 34382511-4 2022 RB005 is a selective SK1 inhibitor and a structural analog of PP2A activator FTY720. Fingolimod Hydrochloride 77-83 protein phosphatase 2 phosphatase activator Homo sapiens 62-66 12711631-22 2003 Overall, the results suggest that FTY720 activated PP2A or PP2A-like phosphatase and dephosphorylated Akt pathway factors resulting in the enhancement of apoptosis via mitochondria. Fingolimod Hydrochloride 34-40 protein phosphatase 2 phosphatase activator Homo sapiens 51-55 12711631-22 2003 Overall, the results suggest that FTY720 activated PP2A or PP2A-like phosphatase and dephosphorylated Akt pathway factors resulting in the enhancement of apoptosis via mitochondria. Fingolimod Hydrochloride 34-40 protein phosphatase 2 phosphatase activator Homo sapiens 59-63 11429058-4 2001 Moreover, FTY720 activates protein phosphatase (PP) 2A and affects anti-apoptotic intracellular signal transduction proteins to attenuate the anti-apoptotic effect. Fingolimod Hydrochloride 10-16 protein phosphatase 2 phosphatase activator Homo sapiens 27-54 29986744-6 2018 Furthermore, the role of NO in mediating the expression of PP2A was further validated with Z-VAD-FMK (a caspase inhibitor), Carboxy-PTIO (a NO scavenger), okadaic acid (OA, a PP2A inhibitor) and FTY720 (a PP2A agonist) in JS-K treated cells. Fingolimod Hydrochloride 195-201 protein phosphatase 2 phosphatase activator Homo sapiens 59-63 33069748-5 2020 Results revealed that PP2A activity was significantly diminished in inflamed cells but the surprising observation was the cell viability of only 35.99% upon FTY720 treatment in inflamed cells lacking basal PP2A activity. Fingolimod Hydrochloride 157-163 protein phosphatase 2 phosphatase activator Homo sapiens 206-210 30917007-2 2019 Targeting SET with a sphingolipid analog drug fingolimod (FTY720) or ceramide leads to the reactivation of tumor suppressor PP2A. Fingolimod Hydrochloride 46-56 protein phosphatase 2 phosphatase activator Homo sapiens 124-128 30917007-2 2019 Targeting SET with a sphingolipid analog drug fingolimod (FTY720) or ceramide leads to the reactivation of tumor suppressor PP2A. Fingolimod Hydrochloride 58-64 protein phosphatase 2 phosphatase activator Homo sapiens 124-128 33932092-10 2021 Pharmacological activation of PP2A with FTY-720 markedly compromised the growth advantage induced by the SF3B1K700E mutation in vitro and in vivo. Fingolimod Hydrochloride 40-47 protein phosphatase 2 phosphatase activator Homo sapiens 30-34 31593801-5 2020 The PP2A activating drug FTY720 has potent anti-leukemic effects; nevertheless, FTY720 induces cardiotoxicity at the anti-neoplastic dose. Fingolimod Hydrochloride 25-31 protein phosphatase 2 phosphatase activator Homo sapiens 4-8 31593801-5 2020 The PP2A activating drug FTY720 has potent anti-leukemic effects; nevertheless, FTY720 induces cardiotoxicity at the anti-neoplastic dose. Fingolimod Hydrochloride 80-86 protein phosphatase 2 phosphatase activator Homo sapiens 4-8 28813646-9 2017 Finally, we showed that other well-known PP2A activators, including forskolin and FTY720, did not inhibit CIP2A and that their activities were not dependent on CIP2A. Fingolimod Hydrochloride 82-88 protein phosphatase 2 phosphatase activator Homo sapiens 41-45 26023836-3 2015 We treated PC-3 and LNCaP cell lines with the PP2A activators forskolin and FTY720 alone or combined with the PP2A inhibitor okadaic acid. Fingolimod Hydrochloride 76-82 protein phosphatase 2 phosphatase activator Homo sapiens 46-50 27556014-9 2016 Furthermore, drugs such as FTY-720 can activate PP2A isoforms directly. Fingolimod Hydrochloride 27-34 protein phosphatase 2 phosphatase activator Homo sapiens 48-52 26967515-2 2016 Fingolimod is a known PP2A activator that inhibits multiple signalling pathways and has been used extensively in patients with multiple sclerosis and other indications. Fingolimod Hydrochloride 0-10 protein phosphatase 2 phosphatase activator Homo sapiens 22-26 26967515-5 2016 A literature review was carried out to assess safety before the commencement of Phase I trials of the PP2A activator Fingolimod in AML. Fingolimod Hydrochloride 117-127 protein phosphatase 2 phosphatase activator Homo sapiens 102-106 26023836-5 2015 Interestingly, both forskolin and FTY720 dephosphorylated and activated PP2A, impairing proliferation and prostasphere formation and inducing changes in AKT and ERK phosphorylation. Fingolimod Hydrochloride 34-40 protein phosphatase 2 phosphatase activator Homo sapiens 72-76 26023836-7 2015 Treatment with okadaic acid impaired PP2A activation thus demonstrating the antitumoral PP2A-dependent mechanism of action of both forskolin and FTY720. Fingolimod Hydrochloride 145-151 protein phosphatase 2 phosphatase activator Homo sapiens 37-41 26023836-7 2015 Treatment with okadaic acid impaired PP2A activation thus demonstrating the antitumoral PP2A-dependent mechanism of action of both forskolin and FTY720. Fingolimod Hydrochloride 145-151 protein phosphatase 2 phosphatase activator Homo sapiens 88-92 25637283-8 2015 The drug FTY-720 (activator of PP2A) induced apoptosis of pancreatic cancer cells. Fingolimod Hydrochloride 9-16 protein phosphatase 2 phosphatase activator Homo sapiens 31-35 22109829-6 2012 Furthermore, FTY720-induced toxicity in AML leukemic cells was mediated by restoration of PP2A activity, via down-regulation of PP2A inhibitor SET, dephosporylation of PP2A-C(TYR307), and up-regulation of relevant PP2A subunit A and B55alpha. Fingolimod Hydrochloride 13-19 protein phosphatase 2 phosphatase activator Homo sapiens 90-94 25699237-7 2015 We review the mechanisms of functional PP2A activation by drugs such as fingolimod, forskolin, OP449, and perphenazine. Fingolimod Hydrochloride 72-82 protein phosphatase 2 phosphatase activator Homo sapiens 39-43 25207757-10 2014 Interestingly, the effects of the parent compound fingolimod were modulated by the PP2A inhibitor okadaic acid, thus suggesting PP2A as relevant intracellular target. Fingolimod Hydrochloride 50-60 protein phosphatase 2 phosphatase activator Homo sapiens 83-87 25207757-10 2014 Interestingly, the effects of the parent compound fingolimod were modulated by the PP2A inhibitor okadaic acid, thus suggesting PP2A as relevant intracellular target. Fingolimod Hydrochloride 50-60 protein phosphatase 2 phosphatase activator Homo sapiens 128-132 25207757-12 2014 Moreover, differential effects of fingolimod versus its phosphorylated derivative on TLR-activated and antigen-dependent Th1 activation suggest PP2A as an additional target of fingolimod immune therapy. Fingolimod Hydrochloride 34-44 protein phosphatase 2 phosphatase activator Homo sapiens 144-148 22109829-6 2012 Furthermore, FTY720-induced toxicity in AML leukemic cells was mediated by restoration of PP2A activity, via down-regulation of PP2A inhibitor SET, dephosporylation of PP2A-C(TYR307), and up-regulation of relevant PP2A subunit A and B55alpha. Fingolimod Hydrochloride 13-19 protein phosphatase 2 phosphatase activator Homo sapiens 128-132 22109829-6 2012 Furthermore, FTY720-induced toxicity in AML leukemic cells was mediated by restoration of PP2A activity, via down-regulation of PP2A inhibitor SET, dephosporylation of PP2A-C(TYR307), and up-regulation of relevant PP2A subunit A and B55alpha. Fingolimod Hydrochloride 13-19 protein phosphatase 2 phosphatase activator Homo sapiens 128-132 21233840-7 2011 In conclusion, our results show that PP2A inhibition is a common event in AML cells and that PP2A activators, such as forskolin or FTY720, could represent potential novel therapeutic targets in AML. Fingolimod Hydrochloride 131-137 protein phosphatase 2 phosphatase activator Homo sapiens 37-41 21233840-7 2011 In conclusion, our results show that PP2A inhibition is a common event in AML cells and that PP2A activators, such as forskolin or FTY720, could represent potential novel therapeutic targets in AML. Fingolimod Hydrochloride 131-137 protein phosphatase 2 phosphatase activator Homo sapiens 93-97