Astemizole

cytochrome P450 family 2 subfamily J member 2 ; Homo sapiens







20 Article(s)
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Pub. Year
#Total Relationships
1 33312341 6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2. 2020 1
2 33335233 Molecular determinant of substrate binding and specificity of cytochrome P450 2J2. 2020 Dec 17 2
3 29433675 Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme. 2018 Jan 15 1
4 29655687 The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation. 2018 Mar 15 2
5 29759885 Terfenadone is a strong inhibitor of CYP2J2 present in the human liver and intestinal microsomes. 2018 Jun 7
6 28160853 Identification of acetylshikonin as the novel CYP2J2 inhibitor with anti-cancer activity in HepG2 cells. 2017 Jan 15 4
7 28237650 Inhibition and inactivation of human CYP2J2: Implications in cardiac pathophysiology and opportunities in cancer therapy. 2017 Jul 1 1
8 28461575 LKY-047: First Selective Inhibitor of Cytochrome P450 2J2. 2017 Jul 1
9 28958841 Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids. 2017 Dec 15 1
10 29911373 [Research progress of human cytochrome P450 2J2 and its ligands]. 2017 Jan 1
11 26899760 Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine. 2016 Nov 1
12 26048912 Danazol Inhibits Cytochrome P450 2J2 Activity in a Substrate-independent Manner. 2015 Aug 5
13 26209360 Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells. 2015 Oct 5 1
14 24788058 Potential of decursin to inhibit the human cytochrome P450 2J2 isoform. 2014 Aug 3
15 24021950 Activity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes. 2013 Dec 1
16 22328583 Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. 2012 May 3
17 20926621 Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist. 2011 Jan 1
18 19923256 Identification of novel substrates for human cytochrome P450 2J2. 2010 Feb 2
19 12851038 In vitro inhibition of human small intestinal and liver microsomal astemizole O-demethylation: different contribution of CYP2J2 in the small intestine and liver. 2003 Jun 2
20 12386130 Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole. 2002 Nov 6