Title : In vitro inhibition of human small intestinal and liver microsomal astemizole O-demethylation: different contribution of CYP2J2 in the small intestine and liver.

Pub. Date : 2003 Jun

PMID : 12851038






2 Functional Relationships(s)
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Protein Name
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1 All the chemicals inhibited astemizole O-demethylation in recombinant CYP2J2 microsomes. Astemizole cytochrome P450 family 2 subfamily J member 2 Homo sapiens
2 The results suggest that CYP2J2 is involved in astemizole O-demethylation in both the human small intestine and liver; however, the contribution in the liver is lower than in the small intestine. Astemizole cytochrome P450 family 2 subfamily J member 2 Homo sapiens