Title : Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist.

Pub. Date : 2011 Jan

PMID : 20926621






1 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Formation of M20 by human liver microsomes was inhibited 89% by ketoconazole, 75% by astemizole (a CYP2J2 inhibitor), and 43% by CYP3A4 monoclonal antibody. Astemizole cytochrome P450 family 2 subfamily J member 2 Homo sapiens