Iron

synuclein alpha ; Homo sapiens







128 Article(s)
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51 29452354 Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease. 2018 May 1 10
52 29608844 Iron Redox Chemistry Promotes Antiparallel Oligomerization of α-Synuclein. 2018 Apr 18 1
53 29681846 High Dietary Iron Supplement Induces the Nigrostriatal Dopaminergic Neurons Lesion in Transgenic Mice Expressing Mutant A53T Human Alpha-Synuclein. 2018 1
54 27424009 Alpha-synuclein-induced oxidative stress correlates with altered superoxide dismutase and glutathione synthesis in human neuroblastoma SH-SY5Y cells. 2017 Mar 1
55 28138322 Iron Deposition Leads to Neuronal α-Synuclein Pathology by Inducing Autophagy Dysfunction. 2017 5
56 28163159 Mitochondrial ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates α-synuclein expression. 2017 May 1
57 28236214 Expanded and Wild-type Ataxin-3 Modify the Redox Status of SH-SY5Y Cells Overexpressing α-Synuclein. 2017 May 1
58 28424751 Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review. 2017 1
59 28452474 Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species. 2017 May 16 1
60 28476637 The critical role of Nramp1 in degrading α-synuclein oligomers in microglia under iron overload condition. 2017 Aug 3
61 28592304 Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease. 2017 Jun 7 3
62 28651647 Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation. 2017 Jun 26 1
63 28731447 Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease. 2017 4
64 28811225 Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL. 2017 Dec 1
65 28874699 Metal concentrations and distributions in the human olfactory bulb in Parkinson's disease. 2017 Sep 5 1
66 29061112 Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases. 2017 Oct 23 1
67 25833099 α-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons. 2016 Apr 12
68 26545340 Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics. 2016 Oct 1
69 26769358 Differential interaction between iron and mutant alpha-synuclein causes distinctive Parkinsonian phenotypes in Drosophila. 2016 Apr 7
70 27343690 Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease. 2016 Aug 2
71 27769419 Combined in-situ imaging of structural organization and elemental composition of substantia nigra neurons in the elderly. 2016 Dec 1 1
72 24954801 The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases. 2015 1
73 25648629 Insights on the interaction of alpha-synuclein and metals in the pathophysiology of Parkinson's disease. 2015 Mar 2
74 26235306 Removal of multi-substituted nitroaromatic pollutants by zero valent iron: a comparison of performance, kinetics, toxicity and mechanisms. 2015 Sep 14 1
75 26284970 Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium. 2015 Oct 21 1
76 26521482 [The Role of Iron and Alpha-synuclein Interacting in Parkinson's Disease]. 2015 Jun 6
77 24475238 Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels. 2014 1
78 25006697 QM/MM molecular dynamics studies of metal binding proteins. 2014 Jul 8 1
79 23376471 Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators. 2013 Sep 1
80 23454680 Role of α-synuclein aggregation and the nuclear factor E2-related factor 2/heme oxygenase-1 pathway in iron-induced neurotoxicity. 2013 Jun 4
81 24256246 α-Synuclein as a ferrireductase. 2013 Dec 1
82 22500765 Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state. 2012 Apr 4 2
83 22581044 α-Synuclein expression is modulated at the translational level by iron. 2012 Jun 20 10
84 22754573 Chelators in the treatment of iron accumulation in Parkinson's disease. 2012 1
85 22880029 Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes. 2012 2
86 20383623 Oxidative stress partially contributes to iron-induced α-synuclein aggregation in SK-N-SH cells. 2011 Apr 9
87 20690031 Alpha-synuclein aggregation is involved in the toxicity induced by ferric iron to SK-N-SH neuroblastoma cells. 2011 Mar 2
88 21221670 The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen. 2011 Mar 2
89 21426349 AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers. 2011 Jun 1
90 21598363 Photoelectric protein nanofibrils of α-synuclein with embedded iron and phthalocyanine tetrasulfonate. 2011 Jun 27 1
91 22860160 Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders. 2011 Nov 16 1
92 23934922 Generation of ferric iron links oxidative stress to α-synuclein oligomer formation. 2011 2
93 19914207 Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron. 2010 Jan 1 2
94 20005574 Binding of alpha-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes. 2010 Apr 2
95 20141569 Copper binding regulates intracellular alpha-synuclein localisation, aggregation and toxicity. 2010 May 1
96 20144654 In silico evidence for glutathione- and iron-related pathogeneses in Parkinson's disease. 2010 Apr 30 1
97 20502498 Dose- and time-dependent alpha-synuclein aggregation induced by ferric iron in SK-N-SH cells. 2010 Jun 3
98 19166904 Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. 2009 Jul 1
99 19325037 Unique copper-induced oligomers mediate alpha-synuclein toxicity. 2009 Aug 1
100 19399246 Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element. 2009 Mar 5