Pub. Date : 2013 Jun
PMID : 23454680
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron is also believed to serve as a major contributor by inducing oxidative stress and alpha-syn aggregation. | Iron | synuclein alpha | Homo sapiens |
| 2 | Here, we report that down-regulation of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) may contribute to iron-induced alpha-syn aggregation. | Iron | synuclein alpha | Homo sapiens |
| 3 | Inhibition of Nrf2/HO-1 leads to more alpha-syn aggregation and greater toxicity induced by iron, creating a vicious cycle of iron accumulation, alpha-syn aggregation and HO-1 disruption in PD. | Iron | synuclein alpha | Homo sapiens |
| 4 | Inhibition of Nrf2/HO-1 leads to more alpha-syn aggregation and greater toxicity induced by iron, creating a vicious cycle of iron accumulation, alpha-syn aggregation and HO-1 disruption in PD. | Iron | synuclein alpha | Homo sapiens |