Iron

synuclein alpha ; Homo sapiens







128 Article(s)
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1 35054862 Mechanistic Insights Expatiating the Redox-Active-Metal-Mediated Neuronal Degeneration in Parkinson's Disease. 2022 Jan 8 1
2 35172141 Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein. 2022 Feb 15 1
3 35216492 Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson's Disease. 2022 Feb 21 3
4 35417944 [Morphochemical study of alpha-synuclein, iron and iron-containing proteins in the substantia nigra of the brain in Parkinson's disease]. 2022 1
5 32726602 Ferroptosis and its potential role in the physiopathology of Parkinson's Disease. 2021 Jan 2
6 33041329 Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. 2021 May 1
7 33440237 Mini-Review: Is iron-mediated cell death (ferroptosis) an identical factor contributing to the pathogenesis of some neurodegenerative diseases? 2021 Feb 6 1
8 33441545 Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis. 2021 Jan 13 3
9 33664298 Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth. 2021 Mar 4 3
10 33799121 Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies. 2021 May 1
11 34083630 Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss. 2021 Jun 3 1
12 34366375 ATH434 Reverses Colorectal Dysfunction in the A53T Mouse Model of Parkinson's Disease. 2021 1
13 34959389 Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression. 2021 Dec 7 1
14 31900363 Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA. 2020 Jan 21 1
15 31912279 Conservative iron chelation for neurodegenerative diseases such as Parkinson's disease and amyotrophic lateral sclerosis. 2020 Feb 1
16 32025811 Parkinson's disease and iron. 2020 Feb 1
17 32104855 Iron-mediated interaction of alpha synuclein with lipid raft model membranes. 2020 Apr 14 1
18 32108853 Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease. 2020 Mar 27 7
19 32210768 Hepcidin-to-Ferritin Ratio Is Decreased in Astrocytes With Extracellular Alpha-Synuclein and Iron Exposure. 2020 1
20 32318880 The role of alpha-synuclein as ferrireductase in neurodegeneration associated with Parkinson's disease. 2020 May 2
21 32341450 Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. 2020 Oct 1
22 32379419 α-Synuclein Regulates Iron Homeostasis via Preventing Parkin-Mediated DMT1 Ubiquitylation in Parkinson's Disease Models. 2020 Jun 3 7
23 32380365 Iron overload regulate the cytokine of mesenchymal stromal cells through ROS/HIF-1α pathway in Myelodysplastic syndromes. 2020 Apr 25 1
24 32409771 Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation. 2020 Sep 1
25 32574378 H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity. 2020 Sep 3
26 32623334 Brain Hepcidin Suppresses Major Pathologies in Experimental Parkinsonism. 2020 Jul 24 2
27 32629061 Copper and iron ions accelerate the prion-like propagation of α-synuclein: A vicious cycle in Parkinson's disease. 2020 Nov 15 8
28 32760266 Spotlight on Ferroptosis: Iron-Dependent Cell Death in Alzheimer's Disease. 2020 1
29 33035800 SNCA-Rep1 polymorphism correlates with susceptibility and iron deficiency in restless legs syndrome. 2020 Dec 1
30 33096655 Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules. 2020 Oct 21 3
31 33177988 Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells. 2020 1
32 29679389 Down-regulation of natural resistance-associated macrophage protein-1 (Nramp1) is associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/1-methyl-4-phenylpyridinium (MPP+ )-induced α-synuclein accumulation and neurotoxicity. 2019 Feb 1
33 30266679 Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration. 2019 Mar 1
34 30342981 Rosmarinic acid protects against MPTP-induced toxicity and inhibits iron-induced α-synuclein aggregation. 2019 Jan 7
35 30465671 Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn. 2019 Jan 23 2
36 30536543 Atrial fibrillation in β-thalassemia patients with a focus on the role of iron-overload and oxidative stress: A review. 2019 Aug 1
37 30554085 Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease. 2019 Mar 1
38 30590010 Iron Dysregulation in Parkinson's Disease: Focused on the Autophagy-Lysosome Pathway. 2019 Feb 20 1
39 30723395 The Contribution of Iron to Protein Aggregation Disorders in the Central Nervous System. 2019 1
40 30791479 Switching on Endogenous Metal Binding Proteins in Parkinson's Disease. 2019 Feb 19 1
41 30797969 Iron-induced oxidative stress contributes to α-synuclein phosphorylation and up-regulation via polo-like kinase 2 and casein kinase 2. 2019 May 14
42 31233777 Interactions between iron and α-synuclein pathology in Parkinson's disease. 2019 Sep 9
43 31235814 Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression. 2019 Jun 24 1
44 31377220 The role of zinc, copper, manganese and iron in neurodegenerative diseases. 2019 Sep 1
45 31417259 α-synuclein interaction with zero-valent iron nanoparticles accelerates structural rearrangement into amyloid-susceptible structure with increased cytotoxic tendency. 2019 1
46 31447651 Quantitative Susceptibility Mapping and Resting State Network Analyses in Parkinsonian Phenotypes-A Systematic Review of the Literature. 2019 1
47 31456205 Iron Pathophysiology in Parkinson Diseases. 2019 2
48 31658742 Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies. 2019 Oct 10 1
49 29076411 Peptides and their Metal Complexes in Neurodegenerative Diseases: from Structural Studies to Nanomedicine Prospects. 2018 Feb 21 1
50 29376857 The Relevance of Iron in the Pathogenesis of Multiple System Atrophy: A Viewpoint. 2018 3