Pub. Date : 2020 Nov 15
PMID : 32629061
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Copper and iron ions accelerate the prion-like propagation of alpha-synuclein: A vicious cycle in Parkinson"s disease. | Iron | synuclein alpha | Homo sapiens |
| 2 | Here, we reported that copper/iron ions accelerate prion-like propagation of alpha-synuclein fibrils by promoting cellular internalization of alpha-synuclein fibrils, intracellular alpha-synuclein aggregation and the subsequent release of mature fibrils to the extracellular space to induce further propagation. | Iron | synuclein alpha | Homo sapiens |
| 3 | Here, we reported that copper/iron ions accelerate prion-like propagation of alpha-synuclein fibrils by promoting cellular internalization of alpha-synuclein fibrils, intracellular alpha-synuclein aggregation and the subsequent release of mature fibrils to the extracellular space to induce further propagation. | Iron | synuclein alpha | Homo sapiens |
| 4 | Here, we reported that copper/iron ions accelerate prion-like propagation of alpha-synuclein fibrils by promoting cellular internalization of alpha-synuclein fibrils, intracellular alpha-synuclein aggregation and the subsequent release of mature fibrils to the extracellular space to induce further propagation. | Iron | synuclein alpha | Homo sapiens |
| 5 | Mechanistically, copper/iron ions enhanced alpha-synuclein fibrils internalization was mediated by negatively charged membrane heparan sulfate proteoglycans (HSPGs). | Iron | synuclein alpha | Homo sapiens |
| 6 | alpha-Synuclein fibrils formed in the presence of copper/iron ions were more cytotoxic, causing increased ROS production, cell apoptosis, and shortened the lifespan of a C. elegans PD model overexpressing human alpha-synuclein. | Iron | synuclein alpha | Homo sapiens |
| 7 | alpha-Synuclein fibrils formed in the presence of copper/iron ions were more cytotoxic, causing increased ROS production, cell apoptosis, and shortened the lifespan of a C. elegans PD model overexpressing human alpha-synuclein. | Iron | synuclein alpha | Homo sapiens |
| 8 | Together, our results suggest a new role for heavy metal ions, e.g. copper and iron, in the pathogenesis of PD through accelerating prion-like propagation of alpha-synuclein fibrils. | Iron | synuclein alpha | Homo sapiens |