| 1 |
35613620 | ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. | 2022 May 14 |
1 |
| 2 |
33680360 | Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins. | 2021 |
1 |
| 3 |
32605999 | KRASQ61H Preferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non-Small Cell Lung Cancer. | 2020 Sep 1 |
3 |
| 4 |
29433126 | MEK drives BRAF activation through allosteric control of KSR proteins. | 2018 Feb 22 |
1 |
| 5 |
29456689 | Inhibition of the Ras/Raf/extracellular signal-regulated kinase 1/2 signaling pathway by compounds of natural origin for possible treatment of spinal cord injury: An in silico approach. | 2018 Mar |
1 |
| 6 |
30154518 | Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics. | 2018 Aug 28 |
1 |
| 7 |
30300582 | Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors. | 2018 Oct 8 |
1 |
| 8 |
28630043 | The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects. | 2017 Aug 4 |
1 |
| 9 |
27087647 | Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering. | 2016 Apr 18 |
1 |
| 10 |
27523909 | An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling. | 2016 Sep 12 |
2 |
| 11 |
27889448 | Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit. | 2016 Dec 1 |
1 |
| 12 |
25684575 | Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD. | 2015 Mar 3 |
1 |
| 13 |
23657011 | Reciprocal regulation of PKA and Rac signaling. | 2013 May 21 |
2 |
| 14 |
24309939 | Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway. | 2013 Dec 5 |
2 |
| 15 |
25033800 | The allosteric switch and conformational states in Ras GTPase affected by small molecules. | 2013 |
1 |
| 16 |
21386094 | Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. | 2011 Mar 8 |
2 |
| 17 |
21388974 | BRAFV600E: implications for carcinogenesis and molecular therapy. | 2011 Mar |
1 |
| 18 |
20230813 | The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation. | 2010 May 15 |
1 |
| 19 |
20603646 | Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase. | 2010 Aug |
1 |
| 20 |
20700538 | H-Ras nanocluster stability regulates the magnitude of MAPK signal output. | 2010 Aug 5 |
5 |
| 21 |
19776012 | Improved binding of raf to Ras.GDP is correlated with biological activity. | 2009 Nov 13 |
3 |
| 22 |
18562239 | The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. | 2008 |
1 |
| 23 |
17295314 | COMBINE analysis of the specificity of binding of Ras proteins to their effectors. | 2007 May 1 |
1 |
| 24 |
17302736 | Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPgammaS. | 2007 Mar |
1 |
| 25 |
17517660 | NRAS mutation causes a human autoimmune lymphoproliferative syndrome. | 2007 May 22 |
1 |
| 26 |
16289967 | Measuring Ras-family GTP levels in vivo--running hot and cold. | 2005 Oct |
1 |
| 27 |
14530258 | Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation. | 2003 Dec 19 |
1 |
| 28 |
11799108 | A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesion. | 2002 Mar 29 |
2 |
| 29 |
11953426 | Associations of B- and C-Raf with cholesterol, phosphatidylserine, and lipid second messengers: preferential binding of Raf to artificial lipid rafts. | 2002 Jul 5 |
2 |
| 30 |
11034387 | Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway. | 2000 Oct 1 |
2 |
| 31 |
11324435 | Ras farnesyltransferase inhibition: a novel and safe approach for cancer chemotherapy. | 2000 May |
1 |
| 32 |
9665134 | A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. | 1998 Jul 2 |
2 |
| 33 |
9760267 | Transient kinetic studies on the interaction of Ras and the Ras-binding domain of c-Raf-1 reveal rapid equilibration of the complex. | 1998 Oct 6 |
1 |
| 34 |
8972184 | An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ. | 1997 Jan |
2 |
| 35 |
9230043 | Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein. | 1997 Jul 29 |
1 |
| 36 |
8636102 | Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor. | 1996 Mar 22 |
1 |
| 37 |
8756332 | Ras/Rap effector specificity determined by charge reversal. | 1996 Aug |
1 |
| 38 |
7499408 | Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems. | 1995 Dec 1 |
2 |
| 39 |
7542586 | Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. | 1995 Jul 3 |
1 |
| 40 |
7731678 | Identification of the sites of interaction between c-Raf-1 and Ras-GTP. | 1995 Apr 6 |
1 |
| 41 |
8607981 | Interactions between Ras and Raf: key regulatory proteins in cellular transformation. | 1995 Dec |
1 |
| 42 |
8048167 | Raf meets Ras: completing the framework of a signal transduction pathway. | 1994 Jul |
1 |
| 43 |
8071362 | Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP. | 1994 Sep 2 |
1 |
| 44 |
8196769 | Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. | 1994 Jun 2 |
3 |
| 45 |
8307946 | Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation. | 1994 Feb 11 |
1 |
| 46 |
8334704 | Mammalian Ras interacts directly with the serine/threonine kinase Raf. | 1993 Jul 16 |
1 |
| 47 |
8378348 | GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells. | 1993 Sep 15 |
3 |