Title : An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling.

Pub. Date : 2016 Sep 12

PMID : 27523909






2 Functional Relationships(s)
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1 Drug resistance due to dimerization is determined by the position of the alphaC helix stabilized by inhibitor, whereas inhibitor-induced RAF priming and dimerization are the result of inhibitor-induced formation of the RAF/RAS-GTP complex. Guanosine Triphosphate zinc fingers and homeoboxes 2 Homo sapiens
2 Drug resistance due to dimerization is determined by the position of the alphaC helix stabilized by inhibitor, whereas inhibitor-induced RAF priming and dimerization are the result of inhibitor-induced formation of the RAF/RAS-GTP complex. Guanosine Triphosphate zinc fingers and homeoboxes 2 Homo sapiens